Open access. Depression, which is common following acquired brain injury (ABI), has been shown to predict cognitive impairment, rehabilitation outcome, and quality of life. Whilst many studies have examined links between depression and cognitive–affective processing in the non‐ABI population, their applicability to this important clinical group, where cognitive difficulties can be marked, remains unknown. Here, we investigated biases in prospective cognition, which is known to be disrupted in (non‐ABI) depression yet important for well‐being.
Open access. Epilepsy is a serious condition which can profoundly affect an individual’s life. While there is some evidence to suggest an association between antidepressant use and epilepsy and seizures it is conflicting and not conclusive. Antidepressant prescribing is rising in the UK so it is important to quantify absolute risks with individual antidepressants to enable shared decision making with patients. In this study we assess and quantify the association between antidepressant treatment and the risk of epilepsy and seizures in a large cohort of patients diagnosed with depression aged between 20 and 64 years.
To compare the time to withdrawal of allocated treatment, remission and first seizure of 10 AEDs currently used as monotherapy in children and adults with partial onset seizures (simple partial, complex partial or secondary generalised) or generalised tonic-clonic seizures with or without other generalised seizure types (absence, myoclonus).
To investigate potential harm and benefits of antiepileptic drugs (AED) given prophylactically to prevent de novo brain tumour-related epilepsy after craniotomy.. To read the full article, log in using your NHS OpenAthens details.
To investigate potential harm and benefits of antiepileptic drugs (AED) given prophylactically to prevent de novo brain tumour-related epilepsy after craniotomy.. To read the full article, log in using your NHS OpenAthens details.
Editorial. The use of antiepileptic drugs (AED) is common in women of childbearing age. One study1 reported that prenatal AED exposure occurred in 2.19% of all pregnancies in the United States. In the past decade, findings have highlighted that it is no longer sufficient to only consider the association between first-trimester exposure and the risk for structural teratogenicity, because prenatal AED exposure throughout the entire pregnancy can have long-term negative consequences on neurodevelopment. The published studies are limited in scope but have consistently reported that valproate prenatal exposure is associated with lower scores on neuropsychometric batteries during early childhood,2,3 while prenatal exposure to carbamazepine and lamotrigine monotherapies is associated with relatively normal scores. Risks associated with most other AEDs have not been adequately studied, to my knowledge.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Letter. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
Among patients with inflammatory bowel disease, what is the incidence of Parkinson disease, and does earlier exposure to anti–tumor necrosis factor therapy mitigate their risk of Parkinson disease?. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Apathy is a prominent and disabling symptom in Parkinson's disease (PD) and is a multidimensional behaviour, but which dimensions are specifically affected is unclear. Therefore, the aim of this preliminary study was to determine the psychometric properties of the Dimensional Apathy Scale (DAS) and explore the multidimensional profile of apathy in PD patients. Login using your SSSFT NHS OpenAthens for full text. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
In 2017, the International Panel on Diagnosis of Multiple Sclerosis revised the McDonald 2010 criteria for the diagnosis of multiple sclerosis (MS). The new criteria are easier to apply and could lead to more and earlier diagnoses. It is important to validate these criteria globally for their accuracy in clinical practice.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Psychogenic non-epileptic seizures (PNES) are classified with other functional neurological symptoms as ‘Conversion Disorder’, but there are reasons to wonder whether this symptomatology constitutes a distinct entity. To read the full article, log in using your NHS OpenAthens details.
Psychogenic non-epileptic seizures (PNES) are classified with other functional neurological symptoms as ‘Conversion Disorder’, but there are reasons to wonder whether this symptomatology constitutes a distinct entity. To read the full article, log in using your NHS OpenAthens details.
Common childhood mental health disorders are up to five times more frequent in children with neurological conditions than in those without a chronic illness, yet ‘contemporary standards of practice fail to integrate screening and treatment of the comorbidities into routine clinical care’1 and there is a high unmet need for treatment.2 This situation is not unique to neurological conditions; up to 80% of those with a chronic illness and symptoms of a mental health disorder are not in contact with child and adolescent mental health services.3–6 Left untreated, mental health disorders seriously impact social, occupational and educational functioning into adulthood.7 8..... To read the full article, log in using your NHS OpenAthens details.
Open access. Because multiple sclerosis (MS) is a chronic disease causing disability over decades, it is crucial to know if the short-term effects of disease-modifying therapies reported in randomised controlled trials reduce long-term disability. This 10-year prospective observational study of disability outcomes (Expanded Disability Status Scale (EDSS) and utility) was set up, in conjunction with a risk-sharing agreement between payers and producers, to investigate this issue.
Open access. Because multiple sclerosis (MS) is a chronic disease causing disability over decades, it is crucial to know if the short-term effects of disease-modifying therapies reported in randomised controlled trials reduce long-term disability. This 10-year prospective observational study of disability outcomes (Expanded Disability Status Scale (EDSS) and utility) was set up, in conjunction with a risk-sharing agreement between payers and producers, to investigate this issue.
A sequential desk-top task was applied, whose performance required the spatiotemporal attention function step by step, to patients after stroke. The relationship between the sequential task and conventional assessments of cognitive function was also assessed. To read the full article, log in using your MPFT NHS OpenAthens details
Findings In this medical record analysis of 44 patients, MEG provided unique and more focal localization information, including in some electroencephalography and interictal MEG silent cases and in some cases that were nonlocalizable otherwise. Extended-source localization was more suitable for analysis of ictal rhythms than commonly used single-point solutions.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case–control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS.. To read the full article, log in using your NHS OpenAthens details.
Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case–control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS.. To read the full article, log in using your NHS OpenAthens details.
The incidence of epilepsy is higher in older age than at any other period of life. Stroke, dementia, and hypertension are associated with late-onset epilepsy; however, the role of other vascular and lifestyle factors remains unclear.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai