%0 Journal Article %1 deSilva2005Complex %A de Silva, Eric %A Stumpf, Michael P. H. %C Division of Molecular Biosciences, Imperial Collage London, Theoretical Genomics Group, South Kensington Campus, London SW7 2AZ, UK. %D 2005 %I The Royal Society %J Journal of The Royal Society Interface %K classic overview review systems-biology %N 5 %P 419--430 %R 10.1098/rsif.2005.0067 %T Complex networks and simple models in biology %U http://dx.doi.org/10.1098/rsif.2005.0067 %V 2 %X 10.1098/rsif.2005.0067 The analysis of molecular networks, such as transcriptional, metabolic and protein interaction networks, has progressed substantially because of the power of models from statistical physics. Increasingly, the data are becoming so detailed—though not always complete or correct—that the simple models are reaching the limits of their usefulness. Here, we will discuss how network information can be described and to some extent quantified. In particular statistics offers a range of tools, such as model selection, which have not yet been widely applied in the analysis of biological networks. We will also outline a number of present challenges posed by biological network data in systems biology, and the extent to which these can be addressed by new developments in statistics, physics and applied mathematics.

@article{deSilva2005Complex, abstract = {10.1098/rsif.2005.0067 The analysis of molecular networks, such as transcriptional, metabolic and protein interaction networks, has progressed substantially because of the power of models from statistical physics. Increasingly, the data are becoming so detailed\^{a}€”though not always complete or correct\^{a}€”that the simple models are reaching the limits of their usefulness. Here, we will discuss how network information can be described and to some extent quantified. In particular statistics offers a range of tools, such as model selection, which have not yet been widely applied in the analysis of biological networks. We will also outline a number of present challenges posed by biological network data in systems biology, and the extent to which these can be addressed by new developments in statistics, physics and applied mathematics.}, added-at = {2018-12-02T16:09:07.000+0100}, address = {Division of Molecular Biosciences, Imperial Collage London, Theoretical Genomics Group, South Kensington Campus, London SW7 2AZ, UK.}, author = {de Silva, Eric and Stumpf, Michael P. H.}, biburl = {https://www.bibsonomy.org/bibtex/2103afd34b77f97610752dccbef787ddb/karthikraman}, citeulike-article-id = {1036582}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rsif.2005.0067}, citeulike-linkout-1 = {http://rsif.royalsocietypublishing.org/content/2/5/419.abstract}, citeulike-linkout-2 = {http://rsif.royalsocietypublishing.org/content/2/5/419.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/16849202}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=16849202}, day = 22, doi = {10.1098/rsif.2005.0067}, interhash = {008cd7856b79766f7a3d42a51f32a607}, intrahash = {103afd34b77f97610752dccbef787ddb}, issn = {1742-5662}, journal = {Journal of The Royal Society Interface}, keywords = {classic overview review systems-biology}, month = dec, number = 5, pages = {419--430}, pmid = {16849202}, posted-at = {2015-11-10 09:31:27}, priority = {2}, publisher = {The Royal Society}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Complex networks and simple models in biology}, url = {http://dx.doi.org/10.1098/rsif.2005.0067}, volume = 2, year = 2005 }