%0 Journal Article %1 Michael2004xr %A Michael, N %A Ostermann, J %A Sörös, P %A Schwindt, W %A Pfleiderer, B %D 2004 %J Neuropsychobiology %K Middle and Disorders Mental Processing, Diagnostic (Psychophysiology) Resonance Cerebrovascular Stimulation neuroscience Mapping Disorder/classification Non-U.S. Statistical Support, Comparative Study Manual Aged Brain Adult Imaging/*methods Computer-Assisted Male Gov't of Depressive AND Image Female Habituation Studies Research Acoustic Humans Case-Control Magnetic Cortex/*physiopathology Circulation Auditory %N 1 %P 5-9 %T Altered habituation in the auditory cortex in a subgroup of depressed patients by functional magnetic resonance imaging. %V 49 %X The aim of this study was to measure and quantify habituation effects to auditory stimulation within the auditory cortex of 11 depressed patients with major depressive disorder compared to 11 healthy subjects. Habituation was visualized by functional magnetic resonance imaging (fMRI) employing a block design (repeated stimulation with sine tones). A subgroup of patients (n = 5) presented the following abnormal habituation fMRI pattern: significantly lower activation after the first stimulation block (p = 0.05), missing characteristic signal decay to repeated acoustic stimulation and a marked undershoot after each stimulation block. This abnormal pattern may indicate functional deficits in auditory processing occurring with depression, but our results need be confirmed in a larger, more homogeneous patient group. This paradigm may be a useful tool for assessing cortical dysfunction in mood disorders.

@article{Michael2004xr, abstract = {The aim of this study was to measure and quantify habituation effects to auditory stimulation within the auditory cortex of 11 depressed patients with major depressive disorder compared to 11 healthy subjects. Habituation was visualized by functional magnetic resonance imaging (fMRI) employing a block design (repeated stimulation with sine tones). A subgroup of patients (n = 5) presented the following abnormal habituation fMRI pattern: significantly lower activation after the first stimulation block (p = 0.05), missing characteristic signal decay to repeated acoustic stimulation and a marked undershoot after each stimulation block. This abnormal pattern may indicate functional deficits in auditory processing occurring with depression, but our results need be confirmed in a larger, more homogeneous patient group. This paradigm may be a useful tool for assessing cortical dysfunction in mood disorders.}, added-at = {2006-05-30T01:06:19.000+0200}, affiliation = {Department of Psychiatry, University of M{\"u}nster, M{\"u}nster, Germany.}, au = {Michael, N}, author = {Michael, N and Ostermann, J and S{\"o}r{\"o}s, P and Schwindt, W and Pfleiderer, B}, biburl = {https://www.bibsonomy.org/bibtex/22072ac1d2f265d3946fb934b5c98cbd2/asterix}, da = {20040119}, date-added = {2006-05-29 18:55:15 -0400}, date-modified = {2006-05-29 18:55:15 -0400}, dcom = {20040308}, description = {neuroscience literature}, edat = {2004/01/20 05:00}, interhash = {047e53ff4ec8b46765dcd516cb079e95}, intrahash = {2072ac1d2f265d3946fb934b5c98cbd2}, issn = {0302-282X}, jid = {7512895}, journal = {Neuropsychobiology}, keywords = {Middle and Disorders Mental Processing, Diagnostic (Psychophysiology) Resonance Cerebrovascular Stimulation neuroscience Mapping Disorder/classification Non-U.S. Statistical Support, Comparative Study Manual Aged Brain Adult Imaging/*methods Computer-Assisted Male Gov't of Depressive AND Image Female Habituation Studies Research Acoustic Humans Case-Control Magnetic Cortex/*physiopathology Circulation Auditory}, language = {eng}, lr = {20041117}, mhda = {2004/03/09 05:00}, number = 1, own = {NLM}, pages = {5-9}, pmid = {14730193}, pst = {ppublish}, pt = {Journal Article}, pubm = {Print}, so = {Neuropsychobiology 2004 ;49(1):5-9.}, stat = {MEDLINE}, timestamp = {2006-05-30T01:06:19.000+0200}, title = {Altered habituation in the auditory cortex in a subgroup of depressed patients by functional magnetic resonance imaging.}, volume = 49, year = 2004 }