%0 Journal Article %1 Svensson:2003:Neuroreport:12821799 %A Svensson, C I %A Hua, X Y %A Protter, A A %A Powell, H C %A Yaksh, T L %D 2003 %J Neuroreport %K hyperalgesia p38 spinal_cord %N 8 %P 1153-1157 %R 10.1097/01.wnr.0000075448.17390.99 %T Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia %U http://www.ncbi.nlm.nih.gov/pubmed/12821799 %V 14 %X Based on previous work, we hypothesized that activation of spinal NMDA-receptor initiates activation of the p38 mitogen-activated protein kinase (p38 MAPK) pathway, leading to spinal release of prostaglandins and hyperalgesia. Accordingly, we examined the effect of intrathecal SD-282, a selective p38 MAPK inhibitor, on NMDA-induced release of prostaglandin E(2) (PGE(2)) and thermal hyperalgesia. Inhibition of spinal p38 MAPK attenuated both NMDA-evoked release of PGE(2) and thermal hyperalgesia. NMDA injection led to increased phospho-p38 MAPK immunoreactivity in superficial (I-II) dorsal laminae. Co-labeling studies revealed co-localization of activated p38 MAPK predominantly with microglia but also with a small subpopulation of neurons. Taken together these data suggest a role for p38 MAPK in NMDA-induced PGE(2) release and hyperalgesia, and that microglia is involved in spinal nociceptive processing.

@article{Svensson:2003:Neuroreport:12821799, abstract = {Based on previous work, we hypothesized that activation of spinal NMDA-receptor initiates activation of the p38 mitogen-activated protein kinase (p38 MAPK) pathway, leading to spinal release of prostaglandins and hyperalgesia. Accordingly, we examined the effect of intrathecal SD-282, a selective p38 MAPK inhibitor, on NMDA-induced release of prostaglandin E(2) (PGE(2)) and thermal hyperalgesia. Inhibition of spinal p38 MAPK attenuated both NMDA-evoked release of PGE(2) and thermal hyperalgesia. NMDA injection led to increased phospho-p38 MAPK immunoreactivity in superficial (I-II) dorsal laminae. Co-labeling studies revealed co-localization of activated p38 MAPK predominantly with microglia but also with a small subpopulation of neurons. Taken together these data suggest a role for p38 MAPK in NMDA-induced PGE(2) release and hyperalgesia, and that microglia is involved in spinal nociceptive processing.}, added-at = {2012-02-28T19:10:31.000+0100}, author = {Svensson, C I and Hua, X Y and Protter, A A and Powell, H C and Yaksh, T L}, biburl = {https://www.bibsonomy.org/bibtex/2bd8f60a6c9bd41c23e8c4e40d8d4a63c/kilianjay}, description = {Spinal p38 MAP kinase is necessary for NMDA-indu... [Neuroreport. 2003] - PubMed - NCBI}, doi = {10.1097/01.wnr.0000075448.17390.99}, interhash = {048ae03be8855fb55435b686d0afcb02}, intrahash = {bd8f60a6c9bd41c23e8c4e40d8d4a63c}, journal = {Neuroreport}, keywords = {hyperalgesia p38 spinal_cord}, month = jun, number = 8, pages = {1153-1157}, pmid = {12821799}, timestamp = {2012-02-29T08:14:34.000+0100}, title = {Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia}, url = {http://www.ncbi.nlm.nih.gov/pubmed/12821799}, volume = 14, year = 2003 }