%0 Journal Article %1 Kotliar.2009 %A Kotliar, K. E. %A Vilser, W. %A Schmidt-Trucksäss, A. %A Halle, M. %A Lanzl, I. M. %D 2009 %J Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft %K Adult Adult;Aged;Aging/*pathology/*physiology;Biological Aged;Retinal Clocks/*physiology;Female;Humans;Male;Middle Vessels/*anatomy WViCo histology/*physiology;Young {\&} %N 7 %P 609--618 %R 10.1007/s00347-008-1878-9 %T Zeitliche Schwingungen retinaler Gefäßdurchmesser bei Gesunden unterschiedlichen Alters: Temporal oscillations of retinal vessel diameter in healthy volunteers of different age %V 106 %X PURPOSE: We investigated whether temporal oscillations of the retinal vessel diameter, as measured with the dynamic vessel analyzer (DVA), undergo age-related changes. METHODS: Vessel diameters of retinal arterial and venous segments were examined with the DVA in 28 medically healthy volunteers divided into two age groups of 14 persons each: young subjects (21-32 years) and seniors (52-70 years). Continuous temporal records of vessel diameter were mathematically evaluated and divided into high-frequency (period <1.5 s) and low-frequency (period > or =1.5 s) oscillations. RESULTS: The phase difference between temporal arterial and venous vessel diameter records was higher in the young group 0.6 (0.1, 3.3) s median (1st quartile, 3rd quartile) compared with the seniors 0.1 (-0.4, 0.3) s. There was a difference in the periodicity in veins between the groups and, in seniors, between the arteries and the veins. CONCLUSIONS: High-frequency oscillations of vessel diameter correspond to the heartbeat. These were expressed more in seniors. Low-frequency oscillations were well expressed in young subjects. Our results show significant age-related alterations in retinal vessel regulation.

@article{Kotliar.2009, abstract = {PURPOSE: We investigated whether temporal oscillations of the retinal vessel diameter, as measured with the dynamic vessel analyzer (DVA), undergo age-related changes. METHODS: Vessel diameters of retinal arterial and venous segments were examined with the DVA in 28 medically healthy volunteers divided into two age groups of 14 persons each: young subjects (21-32 years) and seniors (52-70 years). Continuous temporal records of vessel diameter were mathematically evaluated and divided into high-frequency (period <1.5 s) and low-frequency (period > or =1.5 s) oscillations. RESULTS: The phase difference between temporal arterial and venous vessel diameter records was higher in the young group [0.6 (0.1, 3.3)] s [median (1st quartile, 3rd quartile)] compared with the seniors [0.1 (-0.4, 0.3) s]. There was a difference in the periodicity in veins between the groups and, in seniors, between the arteries and the veins. CONCLUSIONS: High-frequency oscillations of vessel diameter correspond to the heartbeat. These were expressed more in seniors. Low-frequency oscillations were well expressed in young subjects. Our results show significant age-related alterations in retinal vessel regulation.}, added-at = {2013-10-10T21:29:09.000+0200}, author = {Kotliar, K. E. and Vilser, W. and Schmidt-Trucks{\"a}ss, A. and Halle, M. and Lanzl, I. M.}, biburl = {https://www.bibsonomy.org/bibtex/22b98785635807a603d5c3dc1c290b754/imedos}, doi = {10.1007/s00347-008-1878-9}, interhash = {088596cb05b8c814e52938381df27d0c}, intrahash = {2b98785635807a603d5c3dc1c290b754}, issn = {0941-293X}, journal = {Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft}, keywords = {Adult Adult;Aged;Aging/*pathology/*physiology;Biological Aged;Retinal Clocks/*physiology;Female;Humans;Male;Middle Vessels/*anatomy WViCo histology/*physiology;Young {\&}}, number = 7, pages = {609--618}, timestamp = {2013-10-11T01:11:02.000+0200}, title = {Zeitliche Schwingungen retinaler Gef{\"a}{\ss}durchmesser bei Gesunden unterschiedlichen Alters: [Temporal oscillations of retinal vessel diameter in healthy volunteers of different age]}, volume = 106, year = 2009 }