Article,

Systems biology: Small genome, complex regulation

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Nature Reviews Genetics, 11 (1): 3 (Jan 1, 2010)
DOI: 10.1038/nrg2730

Abstract

Three papers describe transcriptomic, metabolic and proteomic analyses of Mycoplasma pneumoniae, which has one of the smallest genomes among self-replicating bacteria. These studies reveal a surprising degree of complexity at each level, which is not only informative about life with a reduced genome but also provides insights into the regulation of cellular functions in bacteria.

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