%0 Journal Article %1 ham-lam %A Hammad, Hamida %A Lambrecht, Bart N. %C MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND %D 2008 %I NATURE PUBLISHING GROUP %J NATURE REVIEWS IMMUNOLOGY %K asthma %N 3 %P 193-204 %R 10.1038/nri2275 %T Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma %V 8 %X Dendritic cells (DCs) are generally held responsible for initiating and maintaining allergic T helper 2 (TH2)-cell responses to inhaled allergens in asthma. Although the epithelium was initially considered to function solely as a physical barrier, it is now seen as a central player in the T H 2-cell sensitization process by influencing the function of DCs. Clinically relevant allergens, as well as known environmental and genetic risk factors for allergy and asthma, often interfere directly or indirectly with the innate immune functions of airway epithelial cells and DCs. A better understanding of these interactions, ascertained from human and animal studies, might lead to better prevention and treatment of asthma.

@article{ham-lam, abstract = {{Dendritic cells (DCs) are generally held responsible for initiating and maintaining allergic T helper 2 (TH2)-cell responses to inhaled allergens in asthma. Although the epithelium was initially considered to function solely as a physical barrier, it is now seen as a central player in the T H 2-cell sensitization process by influencing the function of DCs. Clinically relevant allergens, as well as known environmental and genetic risk factors for allergy and asthma, often interfere directly or indirectly with the innate immune functions of airway epithelial cells and DCs. A better understanding of these interactions, ascertained from human and animal studies, might lead to better prevention and treatment of asthma.}}, added-at = {2013-01-04T17:41:59.000+0100}, address = {{MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND}}, affiliation = {{Lambrecht, BN (Reprint Author), Erasmus Univ, Dept Pulm Med, Med Ctr, Rotterdam, Netherlands.. Lambrecht, Bart N., Erasmus Univ, Dept Pulm Med, Med Ctr, Rotterdam, Netherlands. Hammad, Hamida, State Univ Ghent Hosp, Dept Resp Dis, Lab Immunolregulat \& Mucosal Immunol, Ghent, Belgium.}}, author = {Hammad, Hamida and Lambrecht, Bart N.}, author-email = {{bart.lambrecht@ugent.be}}, biburl = {https://www.bibsonomy.org/bibtex/2b2abbb3a520a8596e1f8f8cff53d8c39/jehiorns}, doc-delivery-number = {{267ZV}}, doi = {{10.1038/nri2275}}, interhash = {0b1cd18478e94eac6331917d121d341b}, intrahash = {b2abbb3a520a8596e1f8f8cff53d8c39}, issn = {{1474-1733}}, journal = {{NATURE REVIEWS IMMUNOLOGY}}, journal-iso = {{Nat. Rev. Immunol.}}, keywords = {asthma}, keywords-plus = {{THYMIC STROMAL LYMPHOPOIETIN; ALLERGIC AIRWAY INFLAMMATION; HOUSE-DUST MITE; BRONCHIAL LYMPH-NODE; REGULATORY T-CELLS; INHALED ANTIGEN; TH2 RESPONSES; MEDIATE TOLERANCE; RESPIRATORY-TRACT; PROTEASE ALLERGEN}}, language = {{English}}, month = {{MAR}}, number = {{3}}, number-of-cited-references = {{131}}, pages = {{193-204}}, publisher = {{NATURE PUBLISHING GROUP}}, research-areas = {{Immunology}}, times-cited = {{197}}, timestamp = {2013-01-04T17:41:59.000+0100}, title = {Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma}, type = {{Review}}, unique-id = {{ISI:000253548600014}}, volume = {{8}}, web-of-science-categories = {{Immunology}}, year = {{2008}} }