%0 Journal Article %1 Lopera-Mesa2013 %A Lopera-Mesa, Tatiana M. %A Doumbia, Saibou %A Chiang, Serena %A Zeituni, Amir E. %A Konate, Drissa S. %A Doumbouya, Mory %A Keita, Abdoul S. %A Stepniewska, Kasia %A Traore, Karim %A Diakite, Seidina A S. %A Ndiaye, Daouda %A Sa, Juliana M. %A Anderson, Jennifer M. %A Fay, Michael P. %A Long, Carole A. %A Diakite, Mahamadou %A Fairhurst, Rick M. %D 2013 %J J Infect Dis %K antimalarials malaria antibodies %N 11 %P 1655--1663 %R 10.1093/infdis/jit082 %T Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity. %U http://dx.doi.org/10.1093/infdis/jit082 %V 207 %X Artemisinin resistance, a long parasite clearance half-life in response to artemisinin, has been described in patients with Plasmodium falciparum malaria in southeast Asia. Few baseline half-lives have been reported from Africa, where artemisinins were recently introduced.We treated P. falciparum malaria in 215 Malian children aged 0.5-15 years with artesunate (0, 24, 48 hours) and amodiaquine (72, 96, 120 hours). We estimated half-life by measuring parasite density every 6 hours until undetectable and evaluated the effects of age, sex, ethnicity, and red blood cell (RBC) polymorphisms on half-life. We quantified the proportion of parasitized RBCs recognized by autologous immunoglobulin G (IgG).The geometric mean half-life was 1.9 hours (95\% confidence interval, 1.8-2.0) and did not correlate with parasite ex vivo susceptibility to artemisinins. In a linear model accounting for host factors, half-life decreased by 4.1 minutes for every 1-year increase in age. The proportion of parasitized RBCs recognized by IgG correlated inversely with half-life (r = -0.475; P = .0006).Parasite clearance in response to artesunate is faster in Mali than in southeast Asia. IgG responses to parasitized RBCs shorten half-life and may influence this parameter in areas where age is not an adequate surrogate of immunity and correlates of parasite-clearing immunity have not been identified.NCT00669084.

@article{Lopera-Mesa2013, abstract = {Artemisinin resistance, a long parasite clearance half-life in response to artemisinin, has been described in patients with Plasmodium falciparum malaria in southeast Asia. Few baseline half-lives have been reported from Africa, where artemisinins were recently introduced.We treated P. falciparum malaria in 215 Malian children aged 0.5-15 years with artesunate (0, 24, 48 hours) and amodiaquine (72, 96, 120 hours). We estimated half-life by measuring parasite density every 6 hours until undetectable and evaluated the effects of age, sex, ethnicity, and red blood cell (RBC) polymorphisms on half-life. We quantified the proportion of parasitized RBCs recognized by autologous immunoglobulin G (IgG).The geometric mean half-life was 1.9 hours (95\% confidence interval, 1.8-2.0) and did not correlate with parasite ex vivo susceptibility to artemisinins. In a linear model accounting for host factors, half-life decreased by 4.1 minutes for every 1-year increase in age. The proportion of parasitized RBCs recognized by IgG correlated inversely with half-life (r = -0.475; P = .0006).Parasite clearance in response to artesunate is faster in Mali than in southeast Asia. IgG responses to parasitized RBCs shorten half-life and may influence this parameter in areas where age is not an adequate surrogate of immunity and correlates of parasite-clearing immunity have not been identified.NCT00669084.}, added-at = {2013-08-19T02:49:40.000+0200}, author = {Lopera-Mesa, Tatiana M. and Doumbia, Saibou and Chiang, Serena and Zeituni, Amir E. and Konate, Drissa S. and Doumbouya, Mory and Keita, Abdoul S. and Stepniewska, Kasia and Traore, Karim and Diakite, Seidina A S. and Ndiaye, Daouda and Sa, Juliana M. and Anderson, Jennifer M. and Fay, Michael P. and Long, Carole A. and Diakite, Mahamadou and Fairhurst, Rick M.}, biburl = {https://www.bibsonomy.org/bibtex/2ae5887acc13b5188c0c0cea3d71fd24d/aorchid}, description = {paper copy. So-so article. Does not say very much at all.}, doi = {10.1093/infdis/jit082}, groups = {public}, institution = {Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.}, interhash = {0dae29f24af20f5427150d7ee6e1300d}, intrahash = {ae5887acc13b5188c0c0cea3d71fd24d}, journal = {J Infect Dis}, keywords = {antimalarials malaria antibodies}, language = {eng}, medline-pst = {ppublish}, month = Jun, number = 11, pages = {1655--1663}, pii = {jit082}, pmid = {23448727}, timestamp = {2013-08-19T02:49:40.000+0200}, title = {Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity.}, url = {http://dx.doi.org/10.1093/infdis/jit082}, username = {aorchid}, volume = 207, year = 2013 }