%0 Journal Article %1 RN64 %A Garcia-Beltran, O. %A Mena, N. %A Friedrich, L.C. %A Netto-Ferreira, J.C. %A Vargas, V. %A Quina, F.H. %A Nunez, M.T. %A Cassels, B.K. %D 2012 %I 2012 Elsevier Ltd. %J Tetrahedron Letters %K atpase, base, chemosensor, copper, coumarin cu+2 cu2+, disease, dqcauchile fluorescence gene ion, probes, schiff sensor, turn-on %N 39 %P 5280-5283 %R 10.1016/j.tetlet.2012.07.082 %T Design and Synthesis of a New Coumarin-Based 'Turn-on' Fluorescent Probe Selective for Cu+2 %U /brokenurl#<Go to ISI>://WOS:000308628900021 %V 53 %X The novel coumarin-based 'turn-on' fluorescent probe (E)-3-(2,5-dimethoxybenzylideneamino)-7-hydroxy-2H-chromen-2-one (MGM) was designed, synthesized, and characterized. This compound shows high selectivity for Cu+2, combined with a large fluorescence enhancement upon binding to Cu2+. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu+2 complex formed is 2:1. Preliminary studies employing epifluorescence microscopy demonstrated that Cu+2 could be imaged in human neuroblastoma SH-SY5Y cells treated with MGM.

@article{RN64, abstract = {The novel coumarin-based 'turn-on' fluorescent probe (E)-3-(2,5-dimethoxybenzylideneamino)-7-hydroxy-2H-chromen-2-one (MGM) was designed, synthesized, and characterized. This compound shows high selectivity for Cu+2, combined with a large fluorescence enhancement upon binding to Cu2+. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu+2 complex formed is 2:1. Preliminary studies employing epifluorescence microscopy demonstrated that Cu+2 could be imaged in human neuroblastoma SH-SY5Y cells treated with MGM. }, added-at = {2019-12-04T03:57:35.000+0100}, author = {Garcia-Beltran, O. and Mena, N. and Friedrich, L.C. and Netto-Ferreira, J.C. and Vargas, V. and Quina, F.H. and Nunez, M.T. and Cassels, B.K.}, biburl = {https://www.bibsonomy.org/bibtex/2a949e5c85c7b8a68ea6526b0adc28998/dqcauchile}, doi = {10.1016/j.tetlet.2012.07.082}, interhash = {0fb54d021942e5d299213e2994c4a7ff}, intrahash = {a949e5c85c7b8a68ea6526b0adc28998}, issn = {0040-4039}, journal = {Tetrahedron Letters}, keywords = {atpase, base, chemosensor, copper, coumarin cu+2 cu2+, disease, dqcauchile fluorescence gene ion, probes, schiff sensor, turn-on}, number = 39, pages = {5280-5283}, publisher = {2012 Elsevier Ltd.}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {Design and Synthesis of a New Coumarin-Based 'Turn-on' Fluorescent Probe Selective for Cu+2}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000308628900021}, volume = 53, year = 2012 }