%0 Journal Article %1 petersen_neisseria_1979 %A Petersen, B H %A Lee, T J %A Snyderman, R %A Brooks, G F %D 1979 %J Annals of Internal Medicine %K Adolescent, Adult, C6, C7, C8, Child, Complement Deficiency Female, Gonorrhea, Homozygote, Humans, Immunologic Infections, Male, Meningococcal Neisseria Recurrence, Risk, Sepsis Syndromes, gonorrhoeae, meningitidis, %N 6 %P 917--920 %T Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency %U http://www.ncbi.nlm.nih.gov/pubmed/109025 %V 90 %X We summarize data from 24 previously described or newly diagnosed cases of homozygous deficiency of the sixth, seventh, or eighth components of complement. Thirteen of 24 patients had at least one episode, and usually two or more episodes of Neisseria meningitidis or Neisseria gonorrhoeae bacteremia, or both. Deficiency of C6, C7, or C8 is a meaningful risk factor for repeated neisserial bacteremia; conversely, hemolytic complement studies are indicated in patients who develop recurrent neisserial infections. When a person with C6, C7, or C8 deficiency is identified, family members should also be studied.

@article{petersen_neisseria_1979, abstract = {We summarize data from 24 previously described or newly diagnosed cases of homozygous deficiency of the sixth, seventh, or eighth components of complement. Thirteen of 24 patients had at least one episode, and usually two or more episodes of Neisseria meningitidis or Neisseria gonorrhoeae bacteremia, or both. Deficiency of C6, C7, or C8 is a meaningful risk factor for repeated neisserial bacteremia; conversely, hemolytic complement studies are indicated in patients who develop recurrent neisserial infections. When a person with C6, C7, or C8 deficiency is identified, family members should also be studied.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Petersen, B H and Lee, T J and Snyderman, R and Brooks, G F}, biburl = {https://www.bibsonomy.org/bibtex/2a85c372352bcb2c8d7bf3b04896265eb/jelias}, interhash = {17ed850dbe90578a15b23f3d63d1c0d1}, intrahash = {a85c372352bcb2c8d7bf3b04896265eb}, issn = {0003-4819}, journal = {Annals of Internal Medicine}, keywords = {Adolescent, Adult, C6, C7, C8, Child, Complement Deficiency Female, Gonorrhea, Homozygote, Humans, Immunologic Infections, Male, Meningococcal Neisseria Recurrence, Risk, Sepsis Syndromes, gonorrhoeae, meningitidis,}, month = jun, note = {{PMID:} 109025}, number = 6, pages = {917--920}, timestamp = {2011-03-11T10:05:39.000+0100}, title = {Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency}, url = {http://www.ncbi.nlm.nih.gov/pubmed/109025}, volume = 90, year = 1979 }