Article,
Multicomponent therapeutics for networked systems
Nat Rev Drug Discov, 4 (1): 71--78 (Jan 1, 2005)
DOI: 10.1038/nrd1609
Abstract
Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations.
