%0 Journal Article %1 Musante2017Quantitative %A Musante, C. J. %A Ramanujan, S. %A Schmidt, B. J. %A Ghobrial, O. G. %A Lu, J. %A Heatherington, A. C. %D 2017 %J Clinical pharmacology and therapeutics %K qsp %N 1 %P 24--27 %T Quantitative Systems Pharmacology: A Case for Disease Models. %U http://view.ncbi.nlm.nih.gov/pubmed/27709613 %V 101 %X Quantitative systems pharmacology (QSP) has emerged as an innovative approach in model-informed drug discovery and development, supporting program decisions from exploratory research through late-stage clinical trials. In this commentary, we discuss the unique value of disease-scale "platform" QSP models that are amenable to reuse and repurposing to support diverse clinical decisions in ways distinct from other pharmacometrics strategies. \copyright 2016 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of The American Society for Clinical Pharmacology and Therapeutics.

@article{Musante2017Quantitative, abstract = {Quantitative systems pharmacology ({QSP}) has emerged as an innovative approach in model-informed drug discovery and development, supporting program decisions from exploratory research through late-stage clinical trials. In this commentary, we discuss the unique value of disease-scale "platform" {QSP} models that are amenable to reuse and repurposing to support diverse clinical decisions in ways distinct from other pharmacometrics strategies. {\copyright} 2016 The Authors Clinical Pharmacology \& Therapeutics published by Wiley Periodicals, Inc. on behalf of The American Society for Clinical Pharmacology and Therapeutics.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Musante, C. J. and Ramanujan, S. and Schmidt, B. J. and Ghobrial, O. G. and Lu, J. and Heatherington, A. C.}, biburl = {https://www.bibsonomy.org/bibtex/2536ff45c18d4effdf02cdd89de794481/karthikraman}, citeulike-article-id = {14381066}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/27709613}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=27709613}, interhash = {32ee35147e50c7f4f8c48d388a2af374}, intrahash = {536ff45c18d4effdf02cdd89de794481}, issn = {1532-6535}, journal = {Clinical pharmacology and therapeutics}, keywords = {qsp}, month = jan, number = 1, pages = {24--27}, pmid = {27709613}, posted-at = {2017-06-22 15:37:48}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Quantitative Systems Pharmacology: A Case for Disease Models.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/27709613}, volume = 101, year = 2017 }