Abstract
Rifampin-resistant meningococcal disease occurred in a child who had completed rifampin chemoprophylaxis for exposure to a sibling with meningococcemia. Susceptibility testing of 331 case isolates found only 1 other case of rifampin-resistant disease in Minnesota, USA, during 11 years of statewide surveillance. Point mutations in the RNA polymerase Beta subunit (rpoB) gene were found in isolates from each rifampin-resistant case-patient.
- agents,
- bacteremia,
- bacterial,
- child,
- drug
- female,
- humans,
- infant,
- infections,
- male,
- meningitidis,
- meningococcal
- microbial
- minnesota,
- mutation,
- neisseria
- point
- polymerases,
- population
- resistance,
- rifampin
- sensitivity
- surveillance,
- tests,
- {anti-bacterial}
- {dna-directed}
- {rna}
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