%0 Journal Article %1 Shefelbine2004 %A Shefelbine, Sandra J %A Carter, Dennis R %D 2004 %J Ann Biomed Eng %K Biomechanics; Bone Development; Cerebral Palsy; Computer Simulation; Diagnosis, Computer-Assisted; Female; Femur Head; Hip Dislocation; Humans; Infant; Male; Mechanotransduction, Cellular; Models, Biological; Muscle, Skeletal; Prognosis; Stress, Mechanical; Weight-Bearing %N 2 %P 297--305 %T Mechanobiological predictions of femoral anteversion in cerebral palsy. %V 32 %X Many morphological changes occur during development of the proximal femur. The anteversion angle is a measure of the rotation of the neck of the femur around the diaphysis. In normal development anteversion is 30 degrees at birth and decreases to 15 degrees by skeletal maturity. In children with cerebral palsy (CP) anteversion often increases slightly and remains high throughout development. Previous models have proposed that cyclic hydrostatic stress decreases the growth rate while cyclic octahedral shear stress increases the growth rate. In this study we also examine changes in the growth direction caused by deformation of the developing cartilage. Using these mechanobiological principles we considered the influence of mechanical loads on the formation of the anteversion angle in normal and CP development. Loads were applied to a three-dimensional finite element model of the proximal femur. From the resulting stresses and deformations at the growth front we calculated the growth rate and growth direction and simulated the progression of the growth front over 6 months. The model predicted a decrease in anteversion angle (-2 degrees over 6 months) under normal-loading conditions, and an increase in anteversion (+ 1 degrees over 6 months) under CP-loading conditions. These results compare well with observations during skeletalgenesis, in which the anteversion angle decreases rapidly in the first few years of normal growth and may increase in children with CP.

@article{Shefelbine2004, abstract = {Many morphological changes occur during development of the proximal femur. The anteversion angle is a measure of the rotation of the neck of the femur around the diaphysis. In normal development anteversion is 30 degrees at birth and decreases to 15 degrees by skeletal maturity. In children with cerebral palsy (CP) anteversion often increases slightly and remains high throughout development. Previous models have proposed that cyclic hydrostatic stress decreases the growth rate while cyclic octahedral shear stress increases the growth rate. In this study we also examine changes in the growth direction caused by deformation of the developing cartilage. Using these mechanobiological principles we considered the influence of mechanical loads on the formation of the anteversion angle in normal and CP development. Loads were applied to a three-dimensional finite element model of the proximal femur. From the resulting stresses and deformations at the growth front we calculated the growth rate and growth direction and simulated the progression of the growth front over 6 months. The model predicted a decrease in anteversion angle (-2 degrees over 6 months) under normal-loading conditions, and an increase in anteversion (+ 1 degrees over 6 months) under CP-loading conditions. These results compare well with observations during skeletalgenesis, in which the anteversion angle decreases rapidly in the first few years of normal growth and may increase in children with CP.}, added-at = {2014-07-19T21:19:58.000+0200}, author = {Shefelbine, Sandra J and Carter, Dennis R}, biburl = {https://www.bibsonomy.org/bibtex/29d530e3802babb6802e4668aa117825b/ar0berts}, groups = {public}, interhash = {3fdae5b9da539d04ae2021f4229b560b}, intrahash = {9d530e3802babb6802e4668aa117825b}, journal = {Ann Biomed Eng}, keywords = {Biomechanics; Bone Development; Cerebral Palsy; Computer Simulation; Diagnosis, Computer-Assisted; Female; Femur Head; Hip Dislocation; Humans; Infant; Male; Mechanotransduction, Cellular; Models, Biological; Muscle, Skeletal; Prognosis; Stress, Mechanical; Weight-Bearing}, month = Feb, number = 2, pages = {297--305}, pmid = {15008378}, timestamp = {2014-07-19T21:19:58.000+0200}, title = {Mechanobiological predictions of femoral anteversion in cerebral palsy.}, username = {ar0berts}, volume = 32, year = 2004 }