Rapid and selective erasures of certain types of memories in the brain would be desirable under certain clinical circumstances. By employing an inducible and reversible chemical-genetic technique, we find that transient alphaCaMKII overexpression at the time of recall impairs the retrieval of both newly formed one-hour object recognition memory and fear memories, as well as 1-month-old fear memories. Systematic analyses suggest that excessive alphaCaMKII activity-induced recall deficits are not caused by disrupting the retrieval access to the stored information but are, rather, due to the active erasure of the stored memories. Further experiments show that the recall-induced erasure of fear memories is highly restricted to the memory being retrieved while leaving other memories intact. Therefore, our study reveals a molecular genetic paradigm through which a given memory, such as new or old fear memory, can be rapidly and specifically erased in a controlled and inducible manner in the brain.
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%0 Journal Article
%1 Cao2008
%A Cao, Xiaohua
%A Wang, Huimin
%A Mei, Bing
%A An, Shuming
%A Yin, Liang
%A Wang, L Phillip
%A Tsien, Joe Z
%D 2008
%I Elsevier Inc.
%J Neuron
%K (Psychology),Conditioning (Psychology),Recognition (Psychology): 2,Cats,Conditioning Animal,Behavior, Animal: Animals,Behavior, Biology,Molecular Biology: Disorders, Disorders,Memory Disorders: Enzymologic,Gene Enzymologic: Expression Factors,Up-Regulation,Up-Regulation: Kinase Post-Traumatic,Stress Post-Traumatic: Protein Regulation, Therapy,Gene Therapy: Transgenic,Molecular Type enzymology,Brain: enzymology,Memory enzymology,Stress genetics genetics,Gene genetics,Memory genetics,Stress methods,Memory methods,Recognition physiology,Brain,Brain: physiology,Fear,Fear: physiology,Gene physiology,Smell,Smell: physiology,Stress physiopathology,Calcium-Calmodulin-Dependent physiopathology,Mice,Mice, therapy,Time
%N 2
%P 353--66
%R 10.1016/j.neuron.2008.08.027
%T Inducible and selective erasure of memories in the mouse brain via chemical-genetic manipulation.
%U http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2955977&tool=pmcentrez&rendertype=abstract
%V 60
%X Rapid and selective erasures of certain types of memories in the brain would be desirable under certain clinical circumstances. By employing an inducible and reversible chemical-genetic technique, we find that transient alphaCaMKII overexpression at the time of recall impairs the retrieval of both newly formed one-hour object recognition memory and fear memories, as well as 1-month-old fear memories. Systematic analyses suggest that excessive alphaCaMKII activity-induced recall deficits are not caused by disrupting the retrieval access to the stored information but are, rather, due to the active erasure of the stored memories. Further experiments show that the recall-induced erasure of fear memories is highly restricted to the memory being retrieved while leaving other memories intact. Therefore, our study reveals a molecular genetic paradigm through which a given memory, such as new or old fear memory, can be rapidly and specifically erased in a controlled and inducible manner in the brain.
@article{Cao2008,
abstract = {Rapid and selective erasures of certain types of memories in the brain would be desirable under certain clinical circumstances. By employing an inducible and reversible chemical-genetic technique, we find that transient alphaCaMKII overexpression at the time of recall impairs the retrieval of both newly formed one-hour object recognition memory and fear memories, as well as 1-month-old fear memories. Systematic analyses suggest that excessive alphaCaMKII activity-induced recall deficits are not caused by disrupting the retrieval access to the stored information but are, rather, due to the active erasure of the stored memories. Further experiments show that the recall-induced erasure of fear memories is highly restricted to the memory being retrieved while leaving other memories intact. Therefore, our study reveals a molecular genetic paradigm through which a given memory, such as new or old fear memory, can be rapidly and specifically erased in a controlled and inducible manner in the brain.},
added-at = {2015-12-01T11:33:23.000+0100},
author = {Cao, Xiaohua and Wang, Huimin and Mei, Bing and An, Shuming and Yin, Liang and Wang, L Phillip and Tsien, Joe Z},
biburl = {https://www.bibsonomy.org/bibtex/258fbc353881979b13912025d82f2a3bf/sofiagruiz92},
doi = {10.1016/j.neuron.2008.08.027},
file = {::},
interhash = {437a8b1cccc9ba568844b74460e799b9},
intrahash = {58fbc353881979b13912025d82f2a3bf},
issn = {1097-4199},
journal = {Neuron},
keywords = {(Psychology),Conditioning (Psychology),Recognition (Psychology): 2,Cats,Conditioning Animal,Behavior, Animal: Animals,Behavior, Biology,Molecular Biology: Disorders, Disorders,Memory Disorders: Enzymologic,Gene Enzymologic: Expression Factors,Up-Regulation,Up-Regulation: Kinase Post-Traumatic,Stress Post-Traumatic: Protein Regulation, Therapy,Gene Therapy: Transgenic,Molecular Type enzymology,Brain: enzymology,Memory enzymology,Stress genetics genetics,Gene genetics,Memory genetics,Stress methods,Memory methods,Recognition physiology,Brain,Brain: physiology,Fear,Fear: physiology,Gene physiology,Smell,Smell: physiology,Stress physiopathology,Calcium-Calmodulin-Dependent physiopathology,Mice,Mice, therapy,Time},
month = oct,
number = 2,
pages = {353--66},
pmid = {18957226},
publisher = {Elsevier Inc.},
timestamp = {2015-12-01T11:33:23.000+0100},
title = {{Inducible and selective erasure of memories in the mouse brain via chemical-genetic manipulation.}},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2955977{\&}tool=pmcentrez{\&}rendertype=abstract},
volume = 60,
year = 2008
}