Zusammenfassung
beta-adrenergic signaling plays a central role in the neurohumoral
regulation of the heart and the progression of heart failure. Initially
thought to be a simple linear cascade, this complex network is now
recognized to utilize cross-talk with numerous other pathways, spatial
compartmentation, and feedback control to coordinate cardiac electrophysiology,
contractility, and adaptive remodeling. Here, we review recent basic
insights and novel quantitative approaches that are leading to a
more comprehensive understanding of beta-adrenergic signaling and
thus motivate new therapeutic strategies for cardiac disease.
Nutzer