%0 Journal Article %1 Pleacher2004 %A Pleacher, Michael D %A Vohr, Betty R %A Katz, Karol H %A Ment, Laura R %A Allan, Walter C %D 2004 %J Pediatrics %K Cerebral Palsy; Child; Child, Preschool; Evidence-Based Medicine; Follow-Up Studies; Humans; Infant, Newborn; Premature; Very Low Birth Weight; Intelligence Tests; Likelihood Functions; Mental Retardation; Neurologic Examination; Randomized Controlled Trials; Sensitivity and Specificity %N 2 %P 416--419 %T An evidence-based approach to predicting low IQ in very preterm infants from the neurological examination: outcome data from the indomethacin Indomethacin Intraventricular Hemorrhage Prevention Trial. %V 113 %X We evaluated whether the degree of cerebral palsy (CP) at age 3 in very preterm children is predictive of full-scale intelligence quotient (FSIQ) <70 at age 8 by calculating likelihood ratios (LRs) for findings on the neurologic examination. Data from the follow-up phase of the Indomethacin Intraventricular Hemorrhage Prevention Trial, which includes periodic neurologic examination and neuropsychometric testing, were used. Information was available on 366 of 440 (83\%) children with birth weight of 600 to 1250 g who survived. Neurologic examination at age 3 was grouped by presence and type of CP, and the Weschler Intelligence Scale for Children-Third Edition FSIQ at age 8 was grouped dichotomously (<70 or > or =70). CP was identified in 35 of 366 3-year-olds (9.5\%). An FSIQ <70 was identified in 47 of 366 children at 8 years old (12.8\%). FSIQ <70 occurred in 14 of 17 children with tri- or quadriplegia (82\%), 8 of 18 children with di- or hemiplegia (44\%), and 25 of 331 children without CP (7.5\%). Useful LRs were calculated for tri- or quadriplegia (30), di- or hemiplegia (5.7), and children without CP (0.55). These LRs have greater impact on posttest odds for FSIQ <70 than those for birth weight <1000 g, history of bronchopulmonary dysplasia, and Stanford-Binet Intelligence Score <70 at age 3. We conclude that the neurologic examination at 3 years old predicts FSIQ <70 at age 8 with LRs that allow evidence-based parental counseling and intervention planning.

@article{Pleacher2004, abstract = {We evaluated whether the degree of cerebral palsy (CP) at age 3 in very preterm children is predictive of full-scale intelligence quotient (FSIQ) <70 at age 8 by calculating likelihood ratios (LRs) for findings on the neurologic examination. Data from the follow-up phase of the Indomethacin Intraventricular Hemorrhage Prevention Trial, which includes periodic neurologic examination and neuropsychometric testing, were used. Information was available on 366 of 440 (83\%) children with birth weight of 600 to 1250 g who survived. Neurologic examination at age 3 was grouped by presence and type of CP, and the Weschler Intelligence Scale for Children-Third Edition FSIQ at age 8 was grouped dichotomously (<70 or > or =70). CP was identified in 35 of 366 3-year-olds (9.5\%). An FSIQ <70 was identified in 47 of 366 children at 8 years old (12.8\%). FSIQ <70 occurred in 14 of 17 children with tri- or quadriplegia (82\%), 8 of 18 children with di- or hemiplegia (44\%), and 25 of 331 children without CP (7.5\%). Useful LRs were calculated for tri- or quadriplegia (30), di- or hemiplegia (5.7), and children without CP (0.55). These LRs have greater impact on posttest odds for FSIQ <70 than those for birth weight <1000 g, history of bronchopulmonary dysplasia, and Stanford-Binet Intelligence Score <70 at age 3. We conclude that the neurologic examination at 3 years old predicts FSIQ <70 at age 8 with LRs that allow evidence-based parental counseling and intervention planning.}, added-at = {2014-07-19T21:03:18.000+0200}, author = {Pleacher, Michael D and Vohr, Betty R and Katz, Karol H and Ment, Laura R and Allan, Walter C}, biburl = {https://www.bibsonomy.org/bibtex/2fbbac8410d35cdc626fcabcf1e4b2edd/ar0berts}, groups = {public}, interhash = {52bb8f09755d2511c4f9395a0d306d47}, intrahash = {fbbac8410d35cdc626fcabcf1e4b2edd}, journal = {Pediatrics}, keywords = {Cerebral Palsy; Child; Child, Preschool; Evidence-Based Medicine; Follow-Up Studies; Humans; Infant, Newborn; Premature; Very Low Birth Weight; Intelligence Tests; Likelihood Functions; Mental Retardation; Neurologic Examination; Randomized Controlled Trials; Sensitivity and Specificity}, month = Feb, number = 2, pages = {416--419}, pmid = {14754962}, timestamp = {2014-07-19T21:03:18.000+0200}, title = {An evidence-based approach to predicting low IQ in very preterm infants from the neurological examination: outcome data from the indomethacin Indomethacin Intraventricular Hemorrhage Prevention Trial.}, username = {ar0berts}, volume = 113, year = 2004 }