Abstract
Aldehyde-terminated self-assembled monolayers (SAMs) on gold surfaces were modified with proteins and employed to capture intact living cells through specific ligand-cell surface receptor interactions. The basic fibroblast growth factor (bFGF) receptor was targeted on baby hamster kidney (BHK-21) cells. The specificity of the receptor-ligand interaction was confirmed by the lack of cell binding to cytochrome c and insulin, and by the disruption of cell binding by treatment with heparitinase.
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