%0 Journal Article %1 Michaud2004 %A Michaud, Andr?-Paul %A Bauman, Nancy M %A Burke, Diane K %A Manaligod, Jos? M %A Smith, Richard J H %D 2004 %J Laryngoscope %K Adolescent; Cerebral Palsy; Child; Child, Preschool; Hemangioma; Humans; Infant; Infant, Newborn; Interferon-alpha; Motor Skills Disorders %N 7 %P 1231--1236 %T Spastic diplegia and other motor disturbances in infants receiving interferon-alpha. %V 114 %X OBJECTIVE: To determine how frequently the use of -interferon (-IFN) is associated with the development of spastic diplegia. STUDY DESIGN AND METHODS: Meta-analysis of 600 English manuscripts published January 1991 to June 2002 reporting -IFN use in infants/children. We identified 3,113 children 18 years of age or younger and an estimated 3,055 children 12 years of age or younger who received -IFN therapy. Sixty-nine percent were treated for chronic hepatitis and 14\% for vascular neoplasms. OUTCOME MEASURE: Neurologic examination to confirm spastic diplegia or a motor developmental disturbance other than spastic diplegia such as hyperactive deep tendon reflexes, gait disturbances, or impaired fine motor control. RESULTS: Including our index case, 11 of 441 children with vascular lesions developed spastic diplegia and an additional 16 of 441 developed a motor developmental disturbance. All of these children were less than 1 year of age at initiation of therapy. Mean age of initiation and duration of -IFN therapy were not significantly different between groups (P >.05); however, motor developmental disturbances improved with cessation of therapy, whereas spastic diplegia did not. No child receiving treatment for chronic hepatitis developed neurologic complications; however, only 49 children were less than 1 year of age at initiation of therapy. CONCLUSION: -IFN should not be used in infants under 1 year of age unless life-threatening conditions do not respond to any other form of treatment. If -IFN must be used, children should have monthly neurologic examinations. If a motor developmental disturbance is detected and -IFN therapy can be discontinued, it should be.

@article{Michaud2004, abstract = {OBJECTIVE: To determine how frequently the use of -interferon (-IFN) is associated with the development of spastic diplegia. STUDY DESIGN AND METHODS: Meta-analysis of 600 English manuscripts published January 1991 to June 2002 reporting -IFN use in infants/children. We identified 3,113 children 18 years of age or younger and an estimated 3,055 children 12 years of age or younger who received -IFN therapy. Sixty-nine percent were treated for chronic hepatitis and 14\% for vascular neoplasms. OUTCOME MEASURE: Neurologic examination to confirm spastic diplegia or a motor developmental disturbance other than spastic diplegia such as hyperactive deep tendon reflexes, gait disturbances, or impaired fine motor control. RESULTS: Including our index case, 11 of 441 children with vascular lesions developed spastic diplegia and an additional 16 of 441 developed a motor developmental disturbance. All of these children were less than 1 year of age at initiation of therapy. Mean age of initiation and duration of -IFN therapy were not significantly different between groups (P >.05); however, motor developmental disturbances improved with cessation of therapy, whereas spastic diplegia did not. No child receiving treatment for chronic hepatitis developed neurologic complications; however, only 49 children were less than 1 year of age at initiation of therapy. CONCLUSION: -IFN should not be used in infants under 1 year of age unless life-threatening conditions do not respond to any other form of treatment. If -IFN must be used, children should have monthly neurologic examinations. If a motor developmental disturbance is detected and -IFN therapy can be discontinued, it should be.}, added-at = {2014-07-19T20:47:46.000+0200}, author = {Michaud, Andr?-Paul and Bauman, Nancy M and Burke, Diane K and Manaligod, Jos? M and Smith, Richard J H}, biburl = {https://www.bibsonomy.org/bibtex/2d75ab34428c2994aef4ceaab52ede5d8/ar0berts}, groups = {public}, interhash = {585030aef448f95c932d959d082848d2}, intrahash = {d75ab34428c2994aef4ceaab52ede5d8}, journal = {Laryngoscope}, keywords = {Adolescent; Cerebral Palsy; Child; Child, Preschool; Hemangioma; Humans; Infant; Infant, Newborn; Interferon-alpha; Motor Skills Disorders}, month = Jul, number = 7, pages = {1231--1236}, pii = {00005537-200407000-00017}, pmid = {15235352}, timestamp = {2014-07-19T20:47:46.000+0200}, title = {Spastic diplegia and other motor disturbances in infants receiving interferon-alpha.}, username = {ar0berts}, volume = 114, year = 2004 }