%0 Journal Article %1 Freeman1988 %A Freeman, R. D. %A Hammaker, R. M. %A Meloan, C. E. %A Fateley, W. G. %D 1988 %I OSA %J Applied Spectroscopy %K chromatography flow\_injection\_analysis raman %N 3 %P 456--460 %T A Detector for Liquid Chromatography and Flow Injection Analysis Using Surface-Enhanced Raman Spectroscopy %U http://www.opticsinfobase.org/abstract.cfm?id=126594 %V 42 %X A successful interface between a high-performance liquid chromatograph and a Raman spectrometer is described. Surface-enhanced techniques are utilized to overcome the sensitivity problem inherent to conventional Raman spectrometry by adding a Ag sol to the chromatographic effluent in a post-column mixing coil. The system is designed so that Raman spectra may be obtained from chromatographic effluent or from flow injection analysis effluent. A common organic dye (pararosaniline hydrochloride) is used to evaluate the reproducibility, dynamic range, and analytical capabilities of the system. The SERS instrument is found to be a viable detector for HPLC and FIA, capable of providing structural information with a sensitivity comparable to that of other commonly used HPLC detectors.

@article{Freeman1988, abstract = {A successful interface between a high-performance liquid chromatograph and a Raman spectrometer is described. Surface-enhanced techniques are utilized to overcome the sensitivity problem inherent to conventional Raman spectrometry by adding a Ag sol to the chromatographic effluent in a post-column mixing coil. The system is designed so that Raman spectra may be obtained from chromatographic effluent or from flow injection analysis effluent. A common organic dye (pararosaniline hydrochloride) is used to evaluate the reproducibility, dynamic range, and analytical capabilities of the system. The SERS instrument is found to be a viable detector for HPLC and FIA, capable of providing structural information with a sensitivity comparable to that of other commonly used HPLC detectors.}, added-at = {2011-10-01T00:25:03.000+0200}, author = {Freeman, R. D. and Hammaker, R. M. and Meloan, C. E. and Fateley, W. G.}, biburl = {https://www.bibsonomy.org/bibtex/2feb2338596a4e38d91099013c7ca7d64/afcallender}, citeulike-article-id = {7651686}, citeulike-linkout-0 = {http://www.opticsinfobase.org/abstract.cfm?id=126594}, day = 1, file = {Freeman1988.pdf:indexed\\Freeman1988.pdf:PDF}, groups = {public}, interhash = {5d3e5bc054266fd3ad46f7207220b07f}, intrahash = {feb2338596a4e38d91099013c7ca7d64}, journal = {Applied Spectroscopy}, keywords = {chromatography flow\_injection\_analysis raman}, month = {March}, number = 3, pages = {456--460}, posted-at = {2010-08-14 20:44:51}, priority = {2}, publisher = {OSA}, timestamp = {2011-10-01T00:25:03.000+0200}, title = {A Detector for Liquid Chromatography and Flow Injection Analysis Using Surface-Enhanced Raman Spectroscopy}, url = {http://www.opticsinfobase.org/abstract.cfm?id=126594}, username = {afcallender}, volume = 42, year = 1988 }