%0 Journal Article %1 Kaizu2010Comprehensive %A Kaizu, Kazunari %A Ghosh, Samik %A Matsuoka, Yukiko %A Moriya, Hisao %A Shimizu-Yoshida, Yuki %A Kitano, Hiroaki %D 2010 %I Nature Publishing Group %J Molecular Systems Biology %K cell-cycle interactome %R 10.1038/msb.2010.73 %T A comprehensive molecular interaction map of the budding yeast cell cycle %U http://dx.doi.org/10.1038/msb.2010.73 %V 6 %X With the accumulation of data on complex molecular machineries coordinating cell-cycle dynamics, coupled with its central function in disease patho-physiologies, it is becoming increasingly important to collate the disparate knowledge sources into a comprehensive molecular network amenable to systems-level analyses. In this work, we present a comprehensive map of the budding yeast cell-cycle, curating reactions from \~600 original papers. Toward leveraging the map as a framework to explore the underlying network architecture, we abstract the molecular components into three planes—signaling, cell-cycle core and structural planes. The planar view together with topological analyses facilitates network-centric identification of functions and control mechanisms. Further, we perform a comparative motif analysis to identify around 194 motifs including feed-forward, mutual inhibitory and feedback mechanisms contributing to cell-cycle robustness. We envisage the open access, comprehensive cell-cycle map to open roads toward community-based deeper understanding of cell-cycle dynamics.

@article{Kaizu2010Comprehensive, abstract = {With the accumulation of data on complex molecular machineries coordinating cell-cycle dynamics, coupled with its central function in disease patho-physiologies, it is becoming increasingly important to collate the disparate knowledge sources into a comprehensive molecular network amenable to systems-level analyses. In this work, we present a comprehensive map of the budding yeast cell-cycle, curating reactions from \~{}600 original papers. Toward leveraging the map as a framework to explore the underlying network architecture, we abstract the molecular components into three planes—signaling, cell-cycle core and structural planes. The planar view together with topological analyses facilitates network-centric identification of functions and control mechanisms. Further, we perform a comparative motif analysis to identify around 194 motifs including feed-forward, mutual inhibitory and feedback mechanisms contributing to cell-cycle robustness. We envisage the open access, comprehensive cell-cycle map to open roads toward community-based deeper understanding of cell-cycle dynamics.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Kaizu, Kazunari and Ghosh, Samik and Matsuoka, Yukiko and Moriya, Hisao and Shimizu-Yoshida, Yuki and Kitano, Hiroaki}, biburl = {https://www.bibsonomy.org/bibtex/2e50d0ed015cbdf609d7e2a94fe04e99a/karthikraman}, citeulike-article-id = {7875918}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/msb.2010.73}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/msb201073}, day = 21, doi = {10.1038/msb.2010.73}, interhash = {65a6a361062c726382e93da56f98b330}, intrahash = {e50d0ed015cbdf609d7e2a94fe04e99a}, journal = {Molecular Systems Biology}, keywords = {cell-cycle interactome}, month = sep, posted-at = {2010-09-22 12:48:14}, priority = {2}, publisher = {Nature Publishing Group}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {A comprehensive molecular interaction map of the budding yeast cell cycle}, url = {http://dx.doi.org/10.1038/msb.2010.73}, volume = 6, year = 2010 }