Abstract
SUMMARY: TOPALi is a new Java graphical analysis application that
allows the user to identify recombinant sequences within a DNA multiple
alignment (either automatically or via manual investigation). TOPALi
allows a choice of three statistical methods to predict the positions
of breakpoints due to past recombination. The breakpoint predictions
are then used to identify putative recombinant sequences and their
relationships to other sequences. In addition to its sophisticated
interface, TOPALi can import many sequence formats, estimate and
display phylogenetic trees and allow interactive analysis and/or
automatic HTML report generation. AVAILABILITY: TOPALi is freely
available from http://www.bioss.ac.uk/software.html
- alignment,sequence
- alignment:
- analysis,
- and
- automated,phylogeny,programming
- computer
- dna,sequence
- dna:
- expression
- genetic,recombination,
- genetic:
- genetics,sequence
- graphics,gene
- interface
- languages,recombination,
- methods,information
- methods,online
- methods,sequence
- methods,software,user-computer
- profiling,gene
- profiling:
- recognition,
- retrieval,information
- retrieval:
- storage
- systems,pattern
Users
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