%0 Journal Article %1 a2007convergent %A Tishkoff, Sarah A %A Reed, Floyd A %A Ranciaro, Alessia %A Voight, Benjamin F %A Babbitt, Courtney C %A Silverman, Jesse S %A Powell, Kweli %A Mortensen, Holly M %A Hirbo, Jibril B %A Osman, Maha %A Ibrahim, Muntaser %A Omar, Sabah A %A Lema, Godfrey %A Nyambo, Thomas B %A Ghori, Jilur %A Bumpstead, Suzannah %A Pritchard, Jonathan K %A Wray, Gregory A %A Deloukas, Panos %D 2007 %J Nat Genet %K adaptation lactase parallel_adaptation %N 1 %P 31--40 %T Convergent adaptation of human lactase persistence in Africa and Europe %U http://dx.doi.org/10.1038/ng1946 %V 39 %X A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association study in 470 Tanzanians, Kenyans and Sudanese and identified three SNPs (G/C-14010, T/G-13915 and C/G-13907) that are associated with lactase persistence and that have derived alleles that significantly enhance transcription from the LCT promoter in vitro. These SNPs originated on different haplotype backgrounds from the European C/T-13910 SNP and from each other. Genotyping across a 3-Mb region demonstrated haplotype homozygosity extending >2.0 Mb on chromosomes carrying C-14010, consistent with a selective sweep over the past approx7,000 years. These data provide a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits—animal domestication and adult milk consumption.

@article{a2007convergent, abstract = {A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association study in 470 Tanzanians, Kenyans and Sudanese and identified three SNPs (G/C-14010, T/G-13915 and C/G-13907) that are associated with lactase persistence and that have derived alleles that significantly enhance transcription from the LCT promoter in vitro. These SNPs originated on different haplotype backgrounds from the European C/T-13910 SNP and from each other. Genotyping across a 3-Mb region demonstrated haplotype homozygosity extending >2.0 Mb on chromosomes carrying C-14010, consistent with a selective sweep over the past approx7,000 years. These data provide a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits—animal domestication and adult milk consumption.}, added-at = {2009-10-31T18:14:46.000+0100}, author = {Tishkoff, Sarah A and Reed, Floyd A and Ranciaro, Alessia and Voight, Benjamin F and Babbitt, Courtney C and Silverman, Jesse S and Powell, Kweli and Mortensen, Holly M and Hirbo, Jibril B and Osman, Maha and Ibrahim, Muntaser and Omar, Sabah A and Lema, Godfrey and Nyambo, Thomas B and Ghori, Jilur and Bumpstead, Suzannah and Pritchard, Jonathan K and Wray, Gregory A and Deloukas, Panos}, biburl = {https://www.bibsonomy.org/bibtex/2c3266938ec5486fc770047faa37f048b/peter.ralph}, description = {Convergent adaptation of human lactase persistence in Africa and Europe : Abstract : Nature Genetics}, interhash = {85a0224ec9baab3e831c8cdf6e89f6b6}, intrahash = {c3266938ec5486fc770047faa37f048b}, issn = {1061-4036}, journal = {Nat Genet}, keywords = {adaptation lactase parallel_adaptation}, month = {#jan#}, number = 1, pages = {31--40}, timestamp = {2011-04-27T22:03:56.000+0200}, title = {Convergent adaptation of human lactase persistence in Africa and Europe}, url = {http://dx.doi.org/10.1038/ng1946}, volume = 39, year = 2007 }