%0 Journal Article %1 Pocock2015a %A Pocock, Stuart J %A Clayton, Tim C %A Stone, Gregg W %D 2015 %J Journal of the American College of Cardiology %K CardiovascularDiseases CardiovascularDiseases:therapy DataInterpretation Humans PatientSelection RandomizedControlledTrialsasTopic:statistics Statistical RCT %N 24 %P 2757-66 %R 10.1016/j.jacc.2015.10.036 %T Design of Major Randomized Trials: Part 3 of a 4-Part Series on Statistics for Clinical Trials. %U http://www.ncbi.nlm.nih.gov/pubmed/26700838 %V 66 %X This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of patients, choice of treatment and control groups, choice of primary and secondary endpoints, methods of randomization, appropriate use of blinding, and determination of trial size. Insights are made with reference to contemporary major trials in cardiology.

@article{Pocock2015a, abstract = {This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of patients, choice of treatment and control groups, choice of primary and secondary endpoints, methods of randomization, appropriate use of blinding, and determination of trial size. Insights are made with reference to contemporary major trials in cardiology.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Pocock, Stuart J and Clayton, Tim C and Stone, Gregg W}, biburl = {https://www.bibsonomy.org/bibtex/26a166ac6951398c9fdacfb6b3f0b8fba/jepcastel}, doi = {10.1016/j.jacc.2015.10.036}, interhash = {966205c6c0b1542297bc232d7dcc4c36}, intrahash = {6a166ac6951398c9fdacfb6b3f0b8fba}, issn = {1558-3597}, journal = {Journal of the American College of Cardiology}, keywords = {CardiovascularDiseases CardiovascularDiseases:therapy DataInterpretation Humans PatientSelection RandomizedControlledTrialsasTopic:statistics Statistical RCT}, month = {12}, note = {Disseny; RCT; Introductori; CV<br/><br/>Exemples i gràfics}, number = 24, pages = {2757-66}, pmid = {26700838}, timestamp = {2023-05-04T09:00:45.000+0200}, title = {Design of Major Randomized Trials: Part 3 of a 4-Part Series on Statistics for Clinical Trials.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/26700838}, volume = 66, year = 2015 }