Аннотация
Background: The planarian Schmidtea mediterranea and the cnidarian
Hydra vulgaris have emerged as valuable model organisms in regeneration
and stem cell research because of their prominent ability to regenerate
a complete organism from any small body fragment. Under natural
conditions wounding may result from predator attacks. These injuries
open their innermost to a wide array of microbes present in the
environment. Therefore, we established the hypothesis that regeneration
processes may be linked to or at least accompanied by innate immune
responses. In order to screen for septic wounding inducible genes we
dissected individuals using a scalpel in the presence of a crude
bacterial lipopolysaccharide preparation that is commonly used to
elicit innate immune responses in animals and applied the suppression
subtractive hybridization technique that selectively amplifies cDNAs of
differentially expressed genes.
Results: This analysis revealed the induced expression of 27 genes in
immune c
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