%0 Journal Article %1 brandtzaeg_plasma_1989 %A Brandtzaeg, P %A Kierulf, P %A Gaustad, P %A Skulberg, A %A Bruun, J N %A Halvorsen, S %A Sørensen, E %D 1989 %J The Journal of Infectious Diseases %K Adolescent, Child, Endotoxins, Failure, Female, Humans, Infant, Lipopolysaccharides, Male, Meningitis, Meningococcal, Multiple Neisseria Organ Preschool, Prognosis, Septic Shock, meningitidis, %N 2 %P 195--204 %T Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease %U http://www.ncbi.nlm.nih.gov/pubmed/2492587 %V 159 %X We studied prospectively the quantitative relation of circulating endotoxin (lipooligosaccharides LOSs) and the development of multiple organ failure and death in 45 consecutively admitted patients with bacteriologically verified systemic meningococcal disease (SMD). A plasma LOS level of greater than 700 ng/L correlated with development of severe septic shock (P less than .0001), adult respiratory distress syndrome (P = .0035), a pathologically elevated serum creatinine level (P less than .0001), or death as a consequence of multiple organ failure (P = .0002). Initial plasma LOS levels of less than 25, 25-700, 700-10,000, and greater than 10,000 ng/L were associated with 0\%, 14\%, 27\%, and 86\% fatality, respectively. The LOS half-life after initiation of antibiotic therapy was 1-3 h. Increasing plasma LOS levels were never seen. These observations suggest that LOS quantitation using the limulus amebocyte lysate assay with a chromogenic substrate gives important progsnotic information and may provide new insight concerning pathophysiological aspects of SMD.

@article{brandtzaeg_plasma_1989, abstract = {We studied prospectively the quantitative relation of circulating endotoxin (lipooligosaccharides {[LOSs])} and the development of multiple organ failure and death in 45 consecutively admitted patients with bacteriologically verified systemic meningococcal disease {(SMD).} A plasma {LOS} level of greater than 700 {ng/L} correlated with development of severe septic shock {(P} less than .0001), adult respiratory distress syndrome {(P} = .0035), a pathologically elevated serum creatinine level {(P} less than .0001), or death as a consequence of multiple organ failure {(P} = .0002). Initial plasma {LOS} levels of less than 25, 25-700, 700-10,000, and greater than 10,000 {ng/L} were associated with 0\%, 14\%, 27\%, and 86\% fatality, respectively. The {LOS} half-life after initiation of antibiotic therapy was 1-3 h. Increasing plasma {LOS} levels were never seen. These observations suggest that {LOS} quantitation using the limulus amebocyte lysate assay with a chromogenic substrate gives important progsnotic information and may provide new insight concerning pathophysiological aspects of {SMD.}}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Brandtzaeg, P and Kierulf, P and Gaustad, P and Skulberg, A and Bruun, J N and Halvorsen, S and Sørensen, E}, biburl = {https://www.bibsonomy.org/bibtex/2707c815661d56600a926bd13242c9b41/jelias}, interhash = {ac2a82fc4508cd477c62165aef4880d7}, intrahash = {707c815661d56600a926bd13242c9b41}, issn = {0022-1899}, journal = {The Journal of Infectious Diseases}, keywords = {Adolescent, Child, Endotoxins, Failure, Female, Humans, Infant, Lipopolysaccharides, Male, Meningitis, Meningococcal, Multiple Neisseria Organ Preschool, Prognosis, Septic Shock, meningitidis,}, month = feb, note = {{PMID:} 2492587}, number = 2, pages = {195--204}, timestamp = {2011-03-11T10:06:01.000+0100}, title = {Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease}, url = {http://www.ncbi.nlm.nih.gov/pubmed/2492587}, volume = 159, year = 1989 }