%0 Journal Article %1 doi:10.1089/cmb.2005.12.283 %A Wendl, Michael C. %D 2005 %J Journal of Computational Biology %K balls-and-bins clone dna %N 3 %P 283-297 %R 10.1089/cmb.2005.12.283 %T Probabilistic Assessment of Clone Overlaps in DNA Fingerprint Mapping via a Priori Models %V 12 %X We construct a combinatorially exact probability distribution for the problem of a priori clone overlap assessment in DNA fingerprint mapping. It is implemented as a general enumeration methodology using Bell’s exponential polynomials. Established computational metrics do not consider the conditional nature of the problem. They dramatically overpredict actual match probabilities as a consequence. This elevates the rate of false-negative overlap declarations, which is consistent with previous validation studies. Increased measurement resolution does not significantly improve accuracy. We describe general trends in error behavior for intermediate-size DNA clones and discuss corresponding limits on the ability to assess certain overlaps.

@article{doi:10.1089/cmb.2005.12.283, abstract = {We construct a combinatorially exact probability distribution for the problem of a priori clone overlap assessment in DNA fingerprint mapping. It is implemented as a general enumeration methodology using Bell’s exponential polynomials. Established computational metrics do not consider the conditional nature of the problem. They dramatically overpredict actual match probabilities as a consequence. This elevates the rate of false-negative overlap declarations, which is consistent with previous validation studies. Increased measurement resolution does not significantly improve accuracy. We describe general trends in error behavior for intermediate-size DNA clones and discuss corresponding limits on the ability to assess certain overlaps.}, added-at = {2013-03-03T00:19:33.000+0100}, author = {Wendl, Michael C.}, biburl = {https://www.bibsonomy.org/bibtex/24359c80e1ab3e7a1162951deb0960b94/ytyoun}, doi = {10.1089/cmb.2005.12.283}, interhash = {b619718a19400273e354c04eb6875189}, intrahash = {4359c80e1ab3e7a1162951deb0960b94}, journal = {Journal of Computational Biology}, keywords = {balls-and-bins clone dna}, note = {PMID: 15857243}, number = 3, pages = {283-297}, timestamp = {2013-03-03T00:19:33.000+0100}, title = {Probabilistic Assessment of Clone Overlaps in DNA Fingerprint Mapping via a Priori Models}, volume = 12, year = 2005 }