%0 Journal Article %1 Wysocki2001 %A Wysocki, M. %A Delatour, F. %A Faurisson, F. %A Rauss, A. %A Pean, Y. %A Misset, B. %A Thomas, F. %A Timsit, J. F. %A Similowski, T. %A Mentec, H. %A Mier, L. %A Dreyfuss, D. %D 2001 %J Antimicrob Agents Chemother %K vancomycin dosing drug %N 9 %P 2460--2467 %R 10.1128/AAC.45.9.2460-2467.2001 %T Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study. %U http://dx.doi.org/10.1128/AAC.45.9.2460-2467.2001 %V 45 %X A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections. A multicenter, prospective, randomized study was designed to compare CIV (targeted plateau drug serum concentrations of 20 to 25 mg/liter) and intermittent infusions of vancomycin (IIV; targeted trough drug serum concentrations of 10 to 15 mg/liter) in 119 critically ill patients with MRS infections (bacteremic infections, 35\%; pneumonia, 45\%). Microbiological and clinical outcomes, safety, pharmacokinetics, ease of treatment adjustment, and cost were compared. Microbiological and clinical outcomes and safety were similar. CIV patients reached the targeted concentrations faster (36 +/- 31 versus 51 +/- 39 h, P = 0.029) and fewer samples were required for treatment monitoring than with IIV patients (7.7 +/- 2.2 versus 11.8 +/- 3.9 per treatment, P < 0.0001). The variability between patients in both the area under the serum concentration-time curve (AUC(24h)) and the daily dose given over 10 days of treatment was lower with CIV than with IIV (variances, 14,621 versus 53,975 mg(2)/liter(2)/h(2) P = 0.026 and 414 versus 818 g(2) P = 0.057, respectively). The 10-day treatment cost per patient was $454 +/- 137 in the IIV group and was 23\% lower in the CIV group ($321 +/- 81: P < 0.0001). In summary, for comparable efficacy and tolerance, CIV may be a cost-effective alternative to IIV.

@article{Wysocki2001, abstract = {A continuous infusion of vancomycin (CIV) may provide an alternative mode of infusion in severe hospital-acquired methicillin-resistant staphylococcal (MRS) infections. A multicenter, prospective, randomized study was designed to compare CIV (targeted plateau drug serum concentrations of 20 to 25 mg/liter) and intermittent infusions of vancomycin (IIV; targeted trough drug serum concentrations of 10 to 15 mg/liter) in 119 critically ill patients with MRS infections (bacteremic infections, 35\%; pneumonia, 45\%). Microbiological and clinical outcomes, safety, pharmacokinetics, ease of treatment adjustment, and cost were compared. Microbiological and clinical outcomes and safety were similar. CIV patients reached the targeted concentrations faster (36 +/- 31 versus 51 +/- 39 h, P = 0.029) and fewer samples were required for treatment monitoring than with IIV patients (7.7 +/- 2.2 versus 11.8 +/- 3.9 per treatment, P < 0.0001). The variability between patients in both the area under the serum concentration-time curve (AUC(24h)) and the daily dose given over 10 days of treatment was lower with CIV than with IIV (variances, 14,621 versus 53,975 mg(2)/liter(2)/h(2) [P = 0.026] and 414 versus 818 g(2) [P = 0.057], respectively). The 10-day treatment cost per patient was $454 +/- 137 in the IIV group and was 23\% lower in the CIV group ($321 +/- 81: P < 0.0001). In summary, for comparable efficacy and tolerance, CIV may be a cost-effective alternative to IIV.}, added-at = {2013-01-07T22:22:59.000+0100}, author = {Wysocki, M. and Delatour, F. and Faurisson, F. and Rauss, A. and Pean, Y. and Misset, B. and Thomas, F. and Timsit, J. F. and Similowski, T. and Mentec, H. and Mier, L. and Dreyfuss, D.}, biburl = {https://www.bibsonomy.org/bibtex/2e01e0493147ac935e50a9013a2c02381/aorchid}, description = {Have paper copy.}, doi = {10.1128/AAC.45.9.2460-2467.2001}, file = {:ID_General/AntimicrobAgentsChemother.45.2460.pdf:PDF}, groups = {public}, institution = {Medico-Surgical Intensive Care Unit, Institut Mutualiste Montsouris, Paris, France. marc.wysocki@imm.fr}, interhash = {bd75233d253f6724015e5270b394e983}, intrahash = {e01e0493147ac935e50a9013a2c02381}, journal = {Antimicrob Agents Chemother}, keywords = {vancomycin dosing drug}, language = {eng}, medline-pst = {ppublish}, month = Sep, number = 9, pages = {2460--2467}, pmid = {11502515}, timestamp = {2013-01-07T22:22:59.000+0100}, title = {Continuous versus intermittent infusion of vancomycin in severe Staphylococcal infections: prospective multicenter randomized study.}, url = {http://dx.doi.org/10.1128/AAC.45.9.2460-2467.2001}, username = {aorchid}, volume = 45, year = 2001 }