%0 Journal Article %1 enderling2015cancer %A Enderling, Heiko %D 2015 %I The Royal Society of Chemistry %J Integr. Biol. %K cancer phd stemcell %P - %R 10.1039/C4IB00191E %T Cancer stem cells: small subpopulation or evolving fraction? %U http://dx.doi.org/10.1039/C4IB00191E %X Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.

@article{enderling2015cancer, abstract = {Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate{,} propagate{,} and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel{,} integrated interdisciplinary studies is offered.}, added-at = {2014-11-18T14:27:28.000+0100}, author = {Enderling, Heiko}, biburl = {https://www.bibsonomy.org/bibtex/23d2830fed2ebca01678a56a4d2e8bbd1/bkoch}, description = {Cancer stem cells: small subpopulation or evolving fraction? - Integrative Biology (RSC Publishing)}, doi = {10.1039/C4IB00191E}, interhash = {c0a58fe666aac1187dfe34942d517f43}, intrahash = {3d2830fed2ebca01678a56a4d2e8bbd1}, journal = {Integr. Biol.}, keywords = {cancer phd stemcell}, pages = {-}, publisher = {The Royal Society of Chemistry}, timestamp = {2014-11-18T14:27:28.000+0100}, title = {Cancer stem cells: small subpopulation or evolving fraction?}, url = {http://dx.doi.org/10.1039/C4IB00191E}, year = 2015 }