%0 Journal Article %1 Ramsey2010Systems %A Ramsey, Stephen A. %A Gold, Elizabeth S. %A Aderem, Alan %D 2010 %J EMBO molecular medicine %K atherosclerosis disease systems-biology %N 3 %P 79--89 %R 10.1002/emmm.201000063 %T A systems biology approach to understanding atherosclerosis. %U http://dx.doi.org/10.1002/emmm.201000063 %V 2 %X Atherosclerosis, a chronic inflammatory disease of the vascular system, presents significant challenges to developing effective molecular diagnostics and novel therapies. A systems biology approach integrating data from large-scale measurements (e.g. transcriptomics, proteomics and genomics) is successfully contributing to deciphering regulatory networks underlying the response of many different cellular systems to perturbations. Such a network analysis strategy using pathway information and data from multiple measurement platforms, tissues and species is a promising approach to elucidate the mechanistic underpinnings of complex diseases. Here, we present our views on the contributions that a systems approach can bring to the study of atherosclerosis, propose ways to tackle the complexity of the disease in a systems manner and review recent systems-level studies of the disease.

@article{Ramsey2010Systems, abstract = { Atherosclerosis, a chronic inflammatory disease of the vascular system, presents significant challenges to developing effective molecular diagnostics and novel therapies. A systems biology approach integrating data from large-scale measurements (e.g. transcriptomics, proteomics and genomics) is successfully contributing to deciphering regulatory networks underlying the response of many different cellular systems to perturbations. Such a network analysis strategy using pathway information and data from multiple measurement platforms, tissues and species is a promising approach to elucidate the mechanistic underpinnings of complex diseases. Here, we present our views on the contributions that a systems approach can bring to the study of atherosclerosis, propose ways to tackle the complexity of the disease in a systems manner and review recent systems-level studies of the disease. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Ramsey, Stephen A. and Gold, Elizabeth S. and Aderem, Alan}, biburl = {https://www.bibsonomy.org/bibtex/25fe5de5dd0f8789a885f0cf878a196c6/karthikraman}, citeulike-article-id = {6767357}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/emmm.201000063}, citeulike-linkout-1 = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992755/}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/20201031}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=20201031}, day = 3, doi = {10.1002/emmm.201000063}, interhash = {c62f400bca8759f093914e65023d3df2}, intrahash = {5fe5de5dd0f8789a885f0cf878a196c6}, issn = {1757-4684}, journal = {EMBO molecular medicine}, keywords = {atherosclerosis disease systems-biology}, month = mar, number = 3, pages = {79--89}, pmcid = {PMC2992755}, pmid = {20201031}, posted-at = {2010-03-05 14:23:53}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {A systems biology approach to understanding atherosclerosis.}, url = {http://dx.doi.org/10.1002/emmm.201000063}, volume = 2, year = 2010 }