Abstract
White matter fiber bundles of the human brain form a spatial pattern
defined by the anatomical and functional architecture. Tractography
applied to the tensor field in diffusion tensor imaging (DTI) results
in sets of streamlines which can be associated with major fiber
tracts. Comparison of fiber tract properties across subjects needs
comparison at corresponding anatomical locations. Moreover, clinical
analysis studying fiber tract disruption and integrity requires
analysis along tracts and within cross-sections, which is hard to
accomplish by conventional region of interest and voxel-based analysis.
We propose a new framework for MR DTI analysis that includes tractography,
fiber clustering, alignment via local shape parametrization and
diffusion analysis across and along tracts. Feasibility is shown
with the uncinate fasciculus and the cortico-spinal tracts. The
extended set of features including fiber tract geometry and diffusion
properties might lead to an improved understanding of diffusion
properties and its association to normal/abnormal brain development.
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