Ryanodine receptors (RyRs), a class of intracellular calcium release
channels, are the largest ion channels known. Recently, cryoelectron
microscopy and image reconstructions of isolated receptors have shown
that most of the protein mass forms a porous, multidomain cytoplasmic
assembly. Evidence is mounting that suggests that the cytoplasmic
assembly communicates with the transmembrane regions over distances
of 100 or greater. RyRs are centrally important in excitation-contraction
coupling, which occurs at specialized regions where the sarcoplasmic
reticulum, containing the RyRs, and the plasma membrane/transverse-tubule
system form junctions. Numerous proteins are present at these junctions,
some of which interact directly with the RyR.
%0 Journal Article
%1 Wage_1997_258
%A Wagenknecht, T.
%A Radermacher, M.
%D 1997
%J Curr. Opin. Struct. Biol.
%K 9094329 Animals, Binding Calcium Calmodulin, Calmodulin-Bindi, Carrier Channel, Channels, Conformation, DNA-Binding Electron, Freezing, Gov't, Heat-Shock Humans, Macromolecular Microscopy, Models, Molecular, Muscle Muscle, Non-U.S. P.H.S., Protei, Protein Proteins, Rabbits, Receptor Release Research Ryanodine Skeletal, Substances, Support, Tacrolimus U.S. ng ns,
%N 2
%P 258--265
%T Ryanodine receptors: structure and macromolecular interactions.
%U http://dx.doi.org/10.1016/S0959-440X(97)80034-6
%V 7
%X Ryanodine receptors (RyRs), a class of intracellular calcium release
channels, are the largest ion channels known. Recently, cryoelectron
microscopy and image reconstructions of isolated receptors have shown
that most of the protein mass forms a porous, multidomain cytoplasmic
assembly. Evidence is mounting that suggests that the cytoplasmic
assembly communicates with the transmembrane regions over distances
of 100 or greater. RyRs are centrally important in excitation-contraction
coupling, which occurs at specialized regions where the sarcoplasmic
reticulum, containing the RyRs, and the plasma membrane/transverse-tubule
system form junctions. Numerous proteins are present at these junctions,
some of which interact directly with the RyR.
@article{Wage_1997_258,
abstract = {Ryanodine receptors (RyRs), a class of intracellular calcium release
channels, are the largest ion channels known. Recently, cryoelectron
microscopy and image reconstructions of isolated receptors have shown
that most of the protein mass forms a porous, multidomain cytoplasmic
assembly. Evidence is mounting that suggests that the cytoplasmic
assembly communicates with the transmembrane regions over distances
of 100 or greater. RyRs are centrally important in excitation-contraction
coupling, which occurs at specialized regions where the sarcoplasmic
reticulum, containing the RyRs, and the plasma membrane/transverse-tubule
system form junctions. Numerous proteins are present at these junctions,
some of which interact directly with the RyR.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Wagenknecht, T. and Radermacher, M.},
biburl = {https://www.bibsonomy.org/bibtex/20ded17beb311bd2e166a2b751b11c2f6/hake},
description = {The whole bibliography file I use.},
file = {Wage_1997_258.pdf:Wage_1997_258.pdf:PDF},
interhash = {51756e25c7bbc8e476c94b12e5c244b8},
intrahash = {0ded17beb311bd2e166a2b751b11c2f6},
journal = {Curr. Opin. Struct. Biol.},
key = 224,
keywords = {9094329 Animals, Binding Calcium Calmodulin, Calmodulin-Bindi, Carrier Channel, Channels, Conformation, DNA-Binding Electron, Freezing, Gov't, Heat-Shock Humans, Macromolecular Microscopy, Models, Molecular, Muscle Muscle, Non-U.S. P.H.S., Protei, Protein Proteins, Rabbits, Receptor Release Research Ryanodine Skeletal, Substances, Support, Tacrolimus U.S. ng ns,},
month = Apr,
number = 2,
pages = {258--265},
pmid = {9094329},
timestamp = {2009-06-03T11:21:35.000+0200},
title = {Ryanodine receptors: structure and macromolecular interactions.},
url = {http://dx.doi.org/10.1016/S0959-440X(97)80034-6},
volume = 7,
year = 1997
}