There is inconsistent evidence that increasing birth order may be associated with risk of non-Hodgkin lymphoma (NHL). The authors examined the association between birth order and related variables and NHL risk in a pooled analysis (1983-2005) of 13,535 cases and 16,427 controls from 18 case-control studies within the International Lymphoma Epidemiology Consortium (InterLymph). Overall, the authors found no significant association between increasing birth order and risk of NHL (P-trend = 0.082) and significant heterogeneity. However, a significant association was present for a number of B- and T-cell NHL subtypes. There was considerable variation in the study-specific risks which was partly explained by study design and participant characteristics. In particular, a significant positive association was present in population-based studies, which had lower response rates in cases and controls, but not in hospital-based studies. A significant positive association was present in higher-socioeconomic-status (SES) participants only. Results were very similar for the related variable of sibship size. The known correlation of high birth order with low SES suggests that selection bias related to SES may be responsible for the association between birth order and NHL.
%0 Journal Article
%1 citeulike:7916226
%A Grulich, Andrew E.
%A Vajdic, Claire M.
%A Falster, Michael O.
%A Kane, Eleanor
%A Smedby, Karin Ekstrom E.
%A Bracci, Paige M.
%A de Sanjose, Silvia
%A Becker, Nikolaus
%A Turner, Jenny
%A Martinez-Maza, Otoniel
%A Melbye, Mads
%A Engels, Eric A.
%A Vineis, Paolo
%A Costantini, Adele Seniori S.
%A Holly, Elizabeth A.
%A Spinelli, John J.
%A La Vecchia, Carlo
%A Zheng, Tongzhang
%A Chiu, Brian C.
%A Franceschi, Silvia
%A Cocco, Pierluigi
%A Maynadié, Marc
%A Foretova, Lenka
%A Staines, Anthony
%A Brennan, Paul
%A Davis, Scott
%A Severson, Richard K.
%A Cerhan, James R.
%A Breen, Elizabeth C.
%A Birmann, Brenda
%A Cozen, Wendy
%D 2010
%I Oxford University Press
%J American journal of epidemiology
%K imported
%N 6
%P 621--630
%R 10.1093/aje/kwq167
%T Birth order and risk of non-hodgkin lymphoma--true association or bias?
%U http://dx.doi.org/10.1093/aje/kwq167
%V 172
%X There is inconsistent evidence that increasing birth order may be associated with risk of non-Hodgkin lymphoma (NHL). The authors examined the association between birth order and related variables and NHL risk in a pooled analysis (1983-2005) of 13,535 cases and 16,427 controls from 18 case-control studies within the International Lymphoma Epidemiology Consortium (InterLymph). Overall, the authors found no significant association between increasing birth order and risk of NHL (P-trend = 0.082) and significant heterogeneity. However, a significant association was present for a number of B- and T-cell NHL subtypes. There was considerable variation in the study-specific risks which was partly explained by study design and participant characteristics. In particular, a significant positive association was present in population-based studies, which had lower response rates in cases and controls, but not in hospital-based studies. A significant positive association was present in higher-socioeconomic-status (SES) participants only. Results were very similar for the related variable of sibship size. The known correlation of high birth order with low SES suggests that selection bias related to SES may be responsible for the association between birth order and NHL.
@article{citeulike:7916226,
abstract = {{
There is inconsistent evidence that increasing birth order may be associated with risk of non-Hodgkin lymphoma (NHL). The authors examined the association between birth order and related variables and NHL risk in a pooled analysis (1983-2005) of 13,535 cases and 16,427 controls from 18 case-control studies within the International Lymphoma Epidemiology Consortium (InterLymph). Overall, the authors found no significant association between increasing birth order and risk of NHL (P-trend = 0.082) and significant heterogeneity. However, a significant association was present for a number of B- and T-cell NHL subtypes. There was considerable variation in the study-specific risks which was partly explained by study design and participant characteristics. In particular, a significant positive association was present in population-based studies, which had lower response rates in cases and controls, but not in hospital-based studies. A significant positive association was present in higher-socioeconomic-status (SES) participants only. Results were very similar for the related variable of sibship size. The known correlation of high birth order with low SES suggests that selection bias related to SES may be responsible for the association between birth order and NHL.
}},
added-at = {2013-04-20T15:12:48.000+0200},
author = {Grulich, Andrew E. and Vajdic, Claire M. and Falster, Michael O. and Kane, Eleanor and Smedby, Karin Ekstrom E. and Bracci, Paige M. and de Sanjose, Silvia and Becker, Nikolaus and Turner, Jenny and Martinez-Maza, Otoniel and Melbye, Mads and Engels, Eric A. and Vineis, Paolo and Costantini, Adele Seniori S. and Holly, Elizabeth A. and Spinelli, John J. and La Vecchia, Carlo and Zheng, Tongzhang and Chiu, Brian C. and Franceschi, Silvia and Cocco, Pierluigi and Maynadi\'{e}, Marc and Foretova, Lenka and Staines, Anthony and Brennan, Paul and Davis, Scott and Severson, Richard K. and Cerhan, James R. and Breen, Elizabeth C. and Birmann, Brenda and Cozen, Wendy},
biburl = {https://www.bibsonomy.org/bibtex/21270bf23b24eacb530aa0b2d8ec78ff3/astaines},
citeulike-article-id = {7916226},
citeulike-linkout-0 = {http://dx.doi.org/10.1093/aje/kwq167},
citeulike-linkout-1 = {http://www.ingentaconnect.com/content/oup/aje/2010/00000172/00000006/art00001},
citeulike-linkout-2 = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950815/},
citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/20720098},
citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=20720098},
day = 15,
doi = {10.1093/aje/kwq167},
interhash = {5187b416b1543eb9ee1881a040c49ca0},
intrahash = {1270bf23b24eacb530aa0b2d8ec78ff3},
issn = {1476-6256},
journal = {American journal of epidemiology},
keywords = {imported},
month = sep,
number = 6,
pages = {621--630},
pmcid = {PMC2950815},
pmid = {20720098},
posted-at = {2013-04-20 12:53:11},
priority = {2},
publisher = {Oxford University Press},
timestamp = {2013-04-20T15:12:55.000+0200},
title = {{Birth order and risk of non-hodgkin lymphoma--true association or bias?}},
url = {http://dx.doi.org/10.1093/aje/kwq167},
volume = 172,
year = 2010
}