%0 Journal Article %1 Lipson1996 %A Lipson, A. H. %A Gillerot, Y. %A Tannenberg, A. E. %A Giurgea, S. %D 1996 %J Eur J Pediatr %K Accidents, Traffic; Adult; Cerebral Palsy; Facial Paralysis; Fatal Outcome; Female; Fetal Hypoxia; Humans; Hypotension; Infant, Newborn; Male; Placental Insufficiency; Pregnancy; Pregnancy Complications; Splenic Rupture %N 9 %P 800--804 %T Two cases of maternal antenatal splenic rupture and hypotension associated with Moebius syndrome and cerebral palsy in offspring. Further evidence for a utero placental vascular aetiology for the Moebius syndrome and some cases of cerebral palsy. %V 155 %X We wish to report two cases of congenital abnormality after antenatal car accidents resulting in ruptured spleen and severe hypotension in the mothers at 8 and 14 weeks gestation. The first case had the classical Moebius syndrome with 6th and 7th cranial nerve palsy with abnormal brain stem evoked responses, presumably due to hypoxic/ischaemic brain stem damage and the second case had severe retardation and hypertonic cerebral palsy which at post mortem was found to be due to old hypoxic/ischaemic lesions to the caudate nucleus putamen and striatum. Conclusion: The cases described provide evidence that severe maternal hypotension during pregnancy can be associated with lesions to the midbrain and brain stem of offspring. The mechanism is probably utero-placental insufficiency, and extrapolation from these two unusual cases would support utero-placental insufficiency as a cause of Moebius syndrome and limb deficiency after chorionic villus sampling.

@article{Lipson1996, abstract = {We wish to report two cases of congenital abnormality after antenatal car accidents resulting in ruptured spleen and severe hypotension in the mothers at 8 and 14 weeks gestation. The first case had the classical Moebius syndrome with 6th and 7th cranial nerve palsy with abnormal brain stem evoked responses, presumably due to hypoxic/ischaemic brain stem damage and the second case had severe retardation and hypertonic cerebral palsy which at post mortem was found to be due to old hypoxic/ischaemic lesions to the caudate nucleus putamen and striatum. Conclusion: The cases described provide evidence that severe maternal hypotension during pregnancy can be associated with lesions to the midbrain and brain stem of offspring. The mechanism is probably utero-placental insufficiency, and extrapolation from these two unusual cases would support utero-placental insufficiency as a cause of Moebius syndrome and limb deficiency after chorionic villus sampling.}, added-at = {2014-07-19T20:42:45.000+0200}, author = {Lipson, A. H. and Gillerot, Y. and Tannenberg, A. E. and Giurgea, S.}, biburl = {https://www.bibsonomy.org/bibtex/2186ca2248f700176ef970f1b657d1050/ar0berts}, groups = {public}, interhash = {6d34fb18c637a87762664375020c7311}, intrahash = {186ca2248f700176ef970f1b657d1050}, journal = {Eur J Pediatr}, keywords = {Accidents, Traffic; Adult; Cerebral Palsy; Facial Paralysis; Fatal Outcome; Female; Fetal Hypoxia; Humans; Hypotension; Infant, Newborn; Male; Placental Insufficiency; Pregnancy; Pregnancy Complications; Splenic Rupture}, month = Sep, number = 9, pages = {800--804}, pmid = {8874116}, timestamp = {2014-07-19T20:42:45.000+0200}, title = {Two cases of maternal antenatal splenic rupture and hypotension associated with Moebius syndrome and cerebral palsy in offspring. Further evidence for a utero placental vascular aetiology for the Moebius syndrome and some cases of cerebral palsy.}, username = {ar0berts}, volume = 155, year = 1996 }