A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the <i>Drosophila melanogaster</i> Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the <i>X</i> chromosome, evidence for positive and negative selection, and rapid evolution of the <i>X</i> chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of <i>Drosophila</i> genetics.
%0 Journal Article
%1 mackay2012drosophila
%A Mackay, Trudy F. C.
%A Richards, Stephen
%A Stone, Eric A.
%A Barbadilla, Antonio
%A Ayroles, Julien F.
%A Zhu, Dianhui
%A Casillas, Sonia
%A Han, Yi
%A Magwire, Michael M.
%A Cridland, Julie M.
%A Richardson, Mark F.
%A Anholt, Robert R. H.
%A Barron, Maite
%A Bess, Crystal
%A Blankenburg, Kerstin Petra
%A Carbone, Mary Anna
%A Castellano, David
%A Chaboub, Lesley
%A Duncan, Laura
%A Harris, Zeke
%A Javaid, Mehwish
%A Jayaseelan, Joy Christina
%A Jhangiani, Shalini N.
%A Jordan, Katherine W.
%A Lara, Fremiet
%A Lawrence, Faye
%A Lee, Sandra L.
%A Librado, Pablo
%A Linheiro, Raquel S.
%A Lyman, Richard F.
%A Mackey, Aaron J.
%A Munidasa, Mala
%A Muzny, Donna Marie
%A Nazareth, Lynne
%A Newsham, Irene
%A Perales, Lora
%A Pu, Ling-Ling
%A Qu, Carson
%A Ramia, Miquel
%A Reid, Jeffrey G.
%A Rollmann, Stephanie M.
%A Rozas, Julio
%A Saada, Nehad
%A Turlapati, Lavanya
%A Worley, Kim C.
%A Wu, Yuan-Qing
%A Yamamoto, Akihiko
%A Zhu, Yiming
%A Bergman, Casey M.
%A Thornton, Kevin R.
%A Mittelman, David
%A Gibbs, Richard A.
%D 2012
%I Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
%J Nature
%K Drosophila descriptive_genomics divergence diversity population_genomics recombination_rates
%N 7384
%P 173--178
%T The Drosophila melanogaster Genetic Reference Panel
%U http://dx.doi.org/10.1038/nature10811
%V 482
%X A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the <i>Drosophila melanogaster</i> Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the <i>X</i> chromosome, evidence for positive and negative selection, and rapid evolution of the <i>X</i> chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of <i>Drosophila</i> genetics.
@article{mackay2012drosophila,
abstract = {A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the <i>Drosophila melanogaster</i> Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the <i>X</i> chromosome, evidence for positive and negative selection, and rapid evolution of the <i>X</i> chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of <i>Drosophila</i> genetics.},
added-at = {2016-08-11T19:33:11.000+0200},
author = {Mackay, Trudy F. C. and Richards, Stephen and Stone, Eric A. and Barbadilla, Antonio and Ayroles, Julien F. and Zhu, Dianhui and Casillas, Sonia and Han, Yi and Magwire, Michael M. and Cridland, Julie M. and Richardson, Mark F. and Anholt, Robert R. H. and Barron, Maite and Bess, Crystal and Blankenburg, Kerstin Petra and Carbone, Mary Anna and Castellano, David and Chaboub, Lesley and Duncan, Laura and Harris, Zeke and Javaid, Mehwish and Jayaseelan, Joy Christina and Jhangiani, Shalini N. and Jordan, Katherine W. and Lara, Fremiet and Lawrence, Faye and Lee, Sandra L. and Librado, Pablo and Linheiro, Raquel S. and Lyman, Richard F. and Mackey, Aaron J. and Munidasa, Mala and Muzny, Donna Marie and Nazareth, Lynne and Newsham, Irene and Perales, Lora and Pu, Ling-Ling and Qu, Carson and Ramia, Miquel and Reid, Jeffrey G. and Rollmann, Stephanie M. and Rozas, Julio and Saada, Nehad and Turlapati, Lavanya and Worley, Kim C. and Wu, Yuan-Qing and Yamamoto, Akihiko and Zhu, Yiming and Bergman, Casey M. and Thornton, Kevin R. and Mittelman, David and Gibbs, Richard A.},
biburl = {https://www.bibsonomy.org/bibtex/21bc8545078b5f3ce273717152f915eae/peter.ralph},
comment = {10.1038/nature10811},
interhash = {4d92f4dc3f1a5f7a3104149bc8216f39},
intrahash = {1bc8545078b5f3ce273717152f915eae},
issn = {00280836},
journal = {Nature},
keywords = {Drosophila descriptive_genomics divergence diversity population_genomics recombination_rates},
month = feb,
number = 7384,
pages = {173--178},
publisher = {Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.},
timestamp = {2016-08-11T19:33:11.000+0200},
title = {The \textit{{Drosophila} melanogaster} Genetic Reference Panel},
url = {http://dx.doi.org/10.1038/nature10811},
volume = 482,
year = 2012
}