%0 Journal Article %1 fang2012incompatibility %A Fang, Shu %A Yukilevich, Roman %A Chen, Ying %A Turissini, David A. %A Zeng, Kai %A Boussy, Ian A. %A Wu, Chung-I. %D 2012 %I Public Library of Science %J PLOS Genetics %K DMI Drosophila experiment hybrid_incompatibility introgression seychellia simulans speciation %N 6 %P 1-10 %R 10.1371/journal.pgen.1002795 %T Incompatibility and Competitive Exclusion of Genomic Segments between Sibling Drosophila Species %U https://doi.org/10.1371/journal.pgen.1002795 %V 8 %X Author Summary Determining the extent of genomic incompatibilities is a pivotal issue in understanding the process of speciation. A controversial topic that has recently sparked debate is whether there are few isolated genetic regions (so-called “genomic islands of speciation”) or extensive genetic regions (“genomic continents of speciation”) responsible for species divergence. To answer this question, most work has focused on species divergence at the DNA sequence level. Here, we present a new perspective by shifting the focus to the fitness and functional aspects of foreign genomic introgression. To illustrate our point, we performed an introgression experiment on two sibling species, D. sechellia and D. simulans. After introgressing random genomic segments of D. sechellia into D. simulans genetic background, a 20-generation competition experiment revealed that, even at the early stages of speciation, there are virtually always detrimental fitness consequences to introducing random foreign elements from one genome to another. This implies that incipient speciation may be characterized by widespread accumulation of genomic incompatibilities rather than a few isolated genes. This study shows that we should move beyond the sterility and inviability assays in order to understand the full extent of genetic incompatibilities during speciation.

@article{fang2012incompatibility, abstract = {Author Summary Determining the extent of genomic incompatibilities is a pivotal issue in understanding the process of speciation. A controversial topic that has recently sparked debate is whether there are few isolated genetic regions (so-called “genomic islands of speciation”) or extensive genetic regions (“genomic continents of speciation”) responsible for species divergence. To answer this question, most work has focused on species divergence at the DNA sequence level. Here, we present a new perspective by shifting the focus to the fitness and functional aspects of foreign genomic introgression. To illustrate our point, we performed an introgression experiment on two sibling species, D. sechellia and D. simulans. After introgressing random genomic segments of D. sechellia into D. simulans genetic background, a 20-generation competition experiment revealed that, even at the early stages of speciation, there are virtually always detrimental fitness consequences to introducing random foreign elements from one genome to another. This implies that incipient speciation may be characterized by widespread accumulation of genomic incompatibilities rather than a few isolated genes. This study shows that we should move beyond the sterility and inviability assays in order to understand the full extent of genetic incompatibilities during speciation.}, added-at = {2017-07-02T16:45:10.000+0200}, author = {Fang, Shu and Yukilevich, Roman and Chen, Ying and Turissini, David A. and Zeng, Kai and Boussy, Ian A. and Wu, Chung-I.}, biburl = {https://www.bibsonomy.org/bibtex/2aeb3c15845f4b6a81bfebfe32af4daf7/peter.ralph}, doi = {10.1371/journal.pgen.1002795}, interhash = {2228a894753071de2324351aa33bcba2}, intrahash = {aeb3c15845f4b6a81bfebfe32af4daf7}, journal = {PLOS Genetics}, keywords = {DMI Drosophila experiment hybrid_incompatibility introgression seychellia simulans speciation}, month = {06}, number = 6, pages = {1-10}, publisher = {Public Library of Science}, timestamp = {2017-07-02T16:45:10.000+0200}, title = {Incompatibility and Competitive Exclusion of Genomic Segments between Sibling Drosophila Species}, url = {https://doi.org/10.1371/journal.pgen.1002795}, volume = 8, year = 2012 }