%0 Journal Article %1 henrickbifidobacteriamediated %A Henrick, Bethany M. %A Rodriguez, Lucie %A Lakshmikanth, Tadepally %A Pou, Christian %A Henckel, Ewa %A Arzoomand, Aron %A Olin, Axel %A Wang, Jun %A Mikes, Jaromir %A Tan, Ziyang %A Chen, Yang %A Ehrlich, Amy M. %A Bernhardsson, Anna Karin %A Mugabo, Constantin Habimana %A Ambrosiani, Ylva %A Gustafsson, Anna %A Chew, Stephanie %A Brown, Heather K. %A Prambs, Johann %A Bohlin, Kajsa %A Mitchell, Ryan D. %A Underwood, Mark A. %A Smilowitz, Jennifer T. %A German, J. Bruce %A Frese, Steven A. %A Brodin, Petter %B Cell %D 2021 %I Elsevier %J Cell %K Bifidobacterium %R 10.1016/j.cell.2021.05.030 %T Bifidobacteria-mediated immune system imprinting early in life %U https://doi.org/10.1016/j.cell.2021.05.030 %X Immune-microbe interactions early in life influence the risk of allergies, asthma, and other inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by providing nutrients to specialized microbes that in turn benefit the host?s immune system. Such bacteria have co-evolved with humans but are now increasingly rare in modern societies. Here we show that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide (HMO) utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life. In breastfed infants given Bifidobacterium infantis EVC001, which expresses all HMO-utilization genes, intestinal T helper 2 (Th2) and Th17 cytokines were silenced and interferon ? (IFN?) was induced. Fecal water from EVC001-supplemented infants contains abundant indolelactate and B. infantis-derived indole-3-lactic acid (ILA) upregulated immunoregulatory galectin-1 in Th2 and Th17 cells during polarization, providing a functional link between beneficial microbes and immunoregulation during the first months of life.

@article{henrickbifidobacteriamediated, abstract = {Immune-microbe interactions early in life influence the risk of allergies, asthma, and other inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by providing nutrients to specialized microbes that in turn benefit the host?s immune system. Such bacteria have co-evolved with humans but are now increasingly rare in modern societies. Here we show that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide (HMO) utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life. In breastfed infants given Bifidobacterium infantis EVC001, which expresses all HMO-utilization genes, intestinal T helper 2 (Th2) and Th17 cytokines were silenced and interferon ? (IFN?) was induced. Fecal water from EVC001-supplemented infants contains abundant indolelactate and B. infantis-derived indole-3-lactic acid (ILA) upregulated immunoregulatory galectin-1 in Th2 and Th17 cells during polarization, providing a functional link between beneficial microbes and immunoregulation during the first months of life.}, added-at = {2021-06-17T17:19:06.000+0200}, author = {Henrick, Bethany M. and Rodriguez, Lucie and Lakshmikanth, Tadepally and Pou, Christian and Henckel, Ewa and Arzoomand, Aron and Olin, Axel and Wang, Jun and Mikes, Jaromir and Tan, Ziyang and Chen, Yang and Ehrlich, Amy M. and Bernhardsson, Anna Karin and Mugabo, Constantin Habimana and Ambrosiani, Ylva and Gustafsson, Anna and Chew, Stephanie and Brown, Heather K. and Prambs, Johann and Bohlin, Kajsa and Mitchell, Ryan D. and Underwood, Mark A. and Smilowitz, Jennifer T. and German, J. Bruce and Frese, Steven A. and Brodin, Petter}, biburl = {https://www.bibsonomy.org/bibtex/22325961bac90e892cd8c964e3f7e6fdc/lkanth}, booktitle = {Cell}, comment = {doi: 10.1016/j.cell.2021.05.030}, description = {Bifidobacteria-mediated immune system imprinting early in life: Cell}, doi = {10.1016/j.cell.2021.05.030}, interhash = {f40e8aa982f64cdb89c461371d5063a9}, intrahash = {2325961bac90e892cd8c964e3f7e6fdc}, issn = {00928674}, journal = {Cell}, keywords = {Bifidobacterium}, publisher = {Elsevier}, timestamp = {2021-06-17T17:19:06.000+0200}, title = {Bifidobacteria-mediated immune system imprinting early in life}, url = {https://doi.org/10.1016/j.cell.2021.05.030}, year = 2021 }