%0 Journal Article %1 Fehlings2000 %A Fehlings, D. %A Rang, M. %A Glazier, J. %A Steele, C. %D 2000 %J J Pediatr %K Analysis of Variance; Arm; Botulinum Toxin Type A; Cerebral Palsy; Chi-Square Distribution; Child; Child, Preschool; Evaluation Studies; Female; Hemiplegia; Humans; Injections, Intramuscular; Male; Neuromuscular Agents; Single-Blind Method; Statistics, Nonparametric; Treatment Outcome %N 3 %P 331--337 %R 10.1067/mpd.2000.108393 %T An evaluation of botulinum-A toxin injections to improve upper extremity function in children with hemiplegic cerebral palsy. %U http://dx.doi.org/10.1067/mpd.2000.108393 %V 137 %X OBJECTIVE: In a randomized, controlled, single-blind trial, to test the hypothesis that botulinum-A toxin (BTA) injections into the upper extremity of children with spastic hemiplegia improve upper extremity function. STUDY DESIGN: Thirty children with hemiplegia, aged 2.5 to 10 years, were randomly assigned to receive: (1) a BTA injection into 1 or more of 3 muscle groups (biceps, volar forearm muscles, adductor pollicis) plus occupational therapy or (2) occupational therapy alone. Blinded outcomes obtained at baseline and at 1, 3, and 6 months included the Quality of Upper Extremity Skills Test (QUEST), goniometry measurements, grip strength, and Ashworth scores. The caregiver completed the self-care domain of the Pediatric Evaluation of Disability Inventory. RESULTS: Twenty-nine subjects completed the study. The QUEST demonstrated a significant improvement favoring the treatment group on a 2-way analysis of variance (F = 4.69, df = 1,83; P =.039). BTA treatment was also associated with an improvement in score on the self-care domain of the Pediatric Evaluation of Disability Inventory (F = 4.68, df = 1,82; P =.04). CONCLUSIONS: This study supports the effectiveness of BTA injections to improve upper extremity function of children with hemiplegia who have at least moderate spasticity.

@article{Fehlings2000, abstract = {OBJECTIVE: In a randomized, controlled, single-blind trial, to test the hypothesis that botulinum-A toxin (BTA) injections into the upper extremity of children with spastic hemiplegia improve upper extremity function. STUDY DESIGN: Thirty children with hemiplegia, aged 2.5 to 10 years, were randomly assigned to receive: (1) a BTA injection into 1 or more of 3 muscle groups (biceps, volar forearm muscles, adductor pollicis) plus occupational therapy or (2) occupational therapy alone. Blinded outcomes obtained at baseline and at 1, 3, and 6 months included the Quality of Upper Extremity Skills Test (QUEST), goniometry measurements, grip strength, and Ashworth scores. The caregiver completed the self-care domain of the Pediatric Evaluation of Disability Inventory. RESULTS: Twenty-nine subjects completed the study. The QUEST demonstrated a significant improvement favoring the treatment group on a 2-way analysis of variance (F = 4.69, df = 1,83; P =.039). BTA treatment was also associated with an improvement in score on the self-care domain of the Pediatric Evaluation of Disability Inventory (F = 4.68, df = 1,82; P =.04). CONCLUSIONS: This study supports the effectiveness of BTA injections to improve upper extremity function of children with hemiplegia who have at least moderate spasticity.}, added-at = {2014-07-19T19:26:08.000+0200}, author = {Fehlings, D. and Rang, M. and Glazier, J. and Steele, C.}, biburl = {https://www.bibsonomy.org/bibtex/226f70ee453a2b5ab0ac8ba23d29fa8ca/ar0berts}, doi = {10.1067/mpd.2000.108393}, groups = {public}, interhash = {f3fc897ac9f3ee95830c007ec2d44603}, intrahash = {26f70ee453a2b5ab0ac8ba23d29fa8ca}, journal = {J Pediatr}, keywords = {Analysis of Variance; Arm; Botulinum Toxin Type A; Cerebral Palsy; Chi-Square Distribution; Child; Child, Preschool; Evaluation Studies; Female; Hemiplegia; Humans; Injections, Intramuscular; Male; Neuromuscular Agents; Single-Blind Method; Statistics, Nonparametric; Treatment Outcome}, month = Sep, number = 3, pages = {331--337}, pii = {S0022-3476(00)18888-2}, pmid = {10969256}, timestamp = {2014-07-19T19:26:08.000+0200}, title = {An evaluation of botulinum-A toxin injections to improve upper extremity function in children with hemiplegic cerebral palsy.}, url = {http://dx.doi.org/10.1067/mpd.2000.108393}, username = {ar0berts}, volume = 137, year = 2000 }