%0 Journal Article %1 zavascki_risk_2006 %A Zavascki, Alexandre Prehn %A Barth, Afonso Luís %A Gaspareto, Patrick Barcelos %A Gonçalves, Ana Lúcia Saraiva %A Moro, Ana Lúcia Didonet %A Fernandes, Juliana Fernandez %A Goldani, Luciano Zubaran %D 2006 %J The Journal of Antimicrobial Chemotherapy %K Adult, Aged, Agents, Cross Factors Female, Fluoroquinolones, Hospitals, Humans, Incidence, Infection, Infections, Male, Middle Pseudomonas Risk Studies, Teaching, aeruginosa, {Anti-Bacterial} {Case-Control} {beta-Lactamases,} {beta-Lactams,} %N 4 %P 882--5 %R 10.1093/jac/dkl327 %T Risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase in two tertiary-care teaching hospitals %U http://www.ncbi.nlm.nih.gov/pubmed/16895936 %V 58 %X OBJECTIVES: To assess risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase (MBL-PA) in two teaching hospitals where horizontal dissemination has been demonstrated. METHODS: A case-control study was performed in both hospitals (assigned as hospital 1 and 2). Cases were patients with MBL-PA infections and controls were those with non-MBL-PA infections. Multivariate analysis was performed to identify independent risk factors. RESULTS: A total of 86 cases and 212 controls were included in the study. A logistic regression model showed that exposure to beta-lactams odds ratio (OR) 3.21; 95\% confidence interval (CI) 1.74-5.93 or fluoroquinolones (OR 3.50; 95\% CI 1.46-8.37) was associated with MBL-PA infections. Other independent risk factors were neurological disease (OR 3.00; 95\% CI 1.61-5.58), urinary tract infection (OR 2.48; 95\% CI 1.21-5.09) and renal failure (OR 2.29; 95\% CI 1.13-4.65). Admission to hospital 1 (OR 5.97; 95\% CI 3.45-14.09) and intensive care unit stay (OR 2.07; 95\% CI 1.46-3.96) were also associated with increased risk for MBL-PA infections. CONCLUSIONS: beta-Lactam exposure is an important risk factor for MBL-PA infections even in a setting where patient-to-patient transmission plays a major role in the spread of the isolates. Other risk factors deserve further investigation, particularly exposure to fluoroquinolones.

@article{zavascki_risk_2006, abstract = {{OBJECTIVES:} To assess risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase {(MBL-PA)} in two teaching hospitals where horizontal dissemination has been demonstrated. {METHODS:} A case-control study was performed in both hospitals (assigned as hospital 1 and 2). Cases were patients with {MBL-PA} infections and controls were those with {non-MBL-PA} infections. Multivariate analysis was performed to identify independent risk factors. {RESULTS:} A total of 86 cases and 212 controls were included in the study. A logistic regression model showed that exposure to beta-lactams [odds ratio {(OR)} 3.21; 95\% confidence interval {(CI)} 1.74-5.93] or fluoroquinolones {(OR} 3.50; 95\% {CI} 1.46-8.37) was associated with {MBL-PA} infections. Other independent risk factors were neurological disease {(OR} 3.00; 95\% {CI} 1.61-5.58), urinary tract infection {(OR} 2.48; 95\% {CI} 1.21-5.09) and renal failure {(OR} 2.29; 95\% {CI} 1.13-4.65). Admission to hospital 1 {(OR} 5.97; 95\% {CI} 3.45-14.09) and intensive care unit stay {(OR} 2.07; 95\% {CI} 1.46-3.96) were also associated with increased risk for {MBL-PA} infections. {CONCLUSIONS:} {beta-Lactam} exposure is an important risk factor for {MBL-PA} infections even in a setting where patient-to-patient transmission plays a major role in the spread of the isolates. Other risk factors deserve further investigation, particularly exposure to fluoroquinolones.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Zavascki, Alexandre Prehn and Barth, Afonso Luís and Gaspareto, Patrick Barcelos and Gonçalves, Ana Lúcia Saraiva and Moro, Ana Lúcia Didonet and Fernandes, Juliana Fernandez and Goldani, Luciano Zubaran}, biburl = {https://www.bibsonomy.org/bibtex/229811950b972d115db2472556dc63e19/jelias}, doi = {10.1093/jac/dkl327}, interhash = {d0c880050355b1532c460930b2f9f056}, intrahash = {29811950b972d115db2472556dc63e19}, issn = {0305-7453}, journal = {The Journal of Antimicrobial Chemotherapy}, keywords = {Adult, Aged, Agents, Cross Factors Female, Fluoroquinolones, Hospitals, Humans, Incidence, Infection, Infections, Male, Middle Pseudomonas Risk Studies, Teaching, aeruginosa, {Anti-Bacterial} {Case-Control} {beta-Lactamases,} {beta-Lactams,}}, month = oct, note = {{PMID:} 16895936}, number = 4, pages = {882--5}, timestamp = {2011-03-11T10:06:33.000+0100}, title = {Risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase in two tertiary-care teaching hospitals}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16895936}, volume = 58, year = 2006 }