%0 Journal Article %1 Ravasi2010Atlas %A Ravasi, Timothy %A Suzuki, Harukazu %A Cannistraci, Carlo V. %A Katayama, Shintaro %A Bajic, Vladimir B. %A Tan, Kai %A Akalin, Altuna %A Schmeier, Sebastian %A Kanamori-Katayama, Mutsumi %A Bertin, Nicolas %A Carninci, Piero %A Daub, Carsten O. %A Forrest, Alistair R. R. %A Gough, Julian %A Grimmond, Sean %A Han, Jung-Hoon %A Hashimoto, Takehiro %A Hide, Winston %A Hofmann, Oliver %A Kamburov, Atanas %A Kaur, Mandeep %A Kawaji, Hideya %A Kubosaki, Atsutaka %A Lassmann, Timo %A van Nimwegen, Erik %A MacPherson, Cameron R. %A Ogawa, Chihiro %A Radovanovic, Aleksandar %A Schwartz, Ariel %A Teasdale, Rohan D. %A Tegnér, Jesper %A Lenhard, Boris %A Teichmann, Sarah A. %A Arakawa, Takahiro %A Ninomiya, Noriko %A Murakami, Kayoko %A Tagami, Michihira %A Fukuda, Shiro %A Imamura, Kengo %A Kai, Chikatoshi %A Ishihara, Ryoko %A Kitazume, Yayoi %A Kawai, Jun %A Hume, David A. %A Ideker, Trey %A Hayashizaki, Yoshihide %D 2010 %I Cell Press %J Cell %K database human mouse transcriptional-regulatory-network %N 5 %P 744--752 %T An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man %U http://www.cell.com//abstract/S0092-8674(10)00079-6 %V 140 %X Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution. º An atlas of human and mouse transcription factor interactions º Quantification of transcription factor expression across human and mouse tissues º A network of 15 transcription factors predicts tissue type specification º SMAD3/FLI1 forms a repressor complex that controls monocyte differentiation

@article{Ravasi2010Atlas, abstract = {Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse {DNA}-binding transcription factors ({TFs}). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected {TFs} are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of {TF} combinations for determining cell fate, and they lead to the identification of a {SMAD3}/{FLI1} complex expressed during development of immunity. The availability of large {TF} combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution. º An atlas of human and mouse transcription factor interactions º Quantification of transcription factor expression across human and mouse tissues º A network of 15 transcription factors predicts tissue type specification º {SMAD3}/{FLI1} forms a repressor complex that controls monocyte differentiation}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Ravasi, Timothy and Suzuki, Harukazu and Cannistraci, Carlo V. and Katayama, Shintaro and Bajic, Vladimir B. and Tan, Kai and Akalin, Altuna and Schmeier, Sebastian and Kanamori-Katayama, Mutsumi and Bertin, Nicolas and Carninci, Piero and Daub, Carsten O. and Forrest, Alistair R. R. and Gough, Julian and Grimmond, Sean and Han, Jung-Hoon and Hashimoto, Takehiro and Hide, Winston and Hofmann, Oliver and Kamburov, Atanas and Kaur, Mandeep and Kawaji, Hideya and Kubosaki, Atsutaka and Lassmann, Timo and van Nimwegen, Erik and MacPherson, Cameron R. and Ogawa, Chihiro and Radovanovic, Aleksandar and Schwartz, Ariel and Teasdale, Rohan D. and Tegn\'{e}r, Jesper and Lenhard, Boris and Teichmann, Sarah A. and Arakawa, Takahiro and Ninomiya, Noriko and Murakami, Kayoko and Tagami, Michihira and Fukuda, Shiro and Imamura, Kengo and Kai, Chikatoshi and Ishihara, Ryoko and Kitazume, Yayoi and Kawai, Jun and Hume, David A. and Ideker, Trey and Hayashizaki, Yoshihide}, biburl = {https://www.bibsonomy.org/bibtex/22aca7bc2eb27c7e2f16c5ee6cd05d2a8/karthikraman}, citeulike-article-id = {6763596}, citeulike-linkout-0 = {http://www.cell.com//abstract/S0092-8674(10)00079-6}, day = 5, interhash = {462a299ec4771bd6af57b319f1feef9a}, intrahash = {2aca7bc2eb27c7e2f16c5ee6cd05d2a8}, journal = {Cell}, keywords = {database human mouse transcriptional-regulatory-network}, month = mar, number = 5, pages = {744--752}, posted-at = {2010-03-10 19:32:00}, priority = {2}, publisher = {Cell Press}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man}, url = {http://www.cell.com//abstract/S0092-8674(10)00079-6}, volume = 140, year = 2010 }