Previous work (Schieber and Hibbard, 1993) has shown that single motor
cortical neurons do not discharge specifically for a particular flexion-extension
finger movement but instead are active with movements of different
fingers. In addition, neuronal populations active with movements
of different fingers overlap extensively in their spatial locations
in the motor cortex. These data suggested that control of any finger
movement utilizes a distributed population of neurons. In this study
we applied the neuronal population vector analysis (Georgopoulos
et al., 1983) to these same data to determine (1) whether single
cells are tuned in an abstract, three-dimensional (3D) instructed
finger and wrist movement space with hand-like geometry and (2) whether
the neuronal population encodes specific finger movements. We found
that the activity of 132/176 (75%) motor cortical neurons related
to finger movements was indeed tuned in this space. Moreover, the
population vector computed in this space predicted well the instructed
finger movement. Thus, although single neurons may be related to
several disparate finger movements, and neurons related to different
finger movements are intermingled throughout the hand area of the
motor cortex, the neuronal population activity does specify particular
finger movements.
%0 Journal Article
%1 Georgopoulos:1999
%A Georgopoulos, Apostolos P.
%A Pellizzer, Giuseppe
%A Poliakov, Andrew V.
%A Schieber, Marc H.
%D 1999
%J Journal of Computational Neuroscience
%K - finger movements population tuning vector
%P 279-288
%T Neural Coding of Finger and Wrist Movements
%V 6
%X Previous work (Schieber and Hibbard, 1993) has shown that single motor
cortical neurons do not discharge specifically for a particular flexion-extension
finger movement but instead are active with movements of different
fingers. In addition, neuronal populations active with movements
of different fingers overlap extensively in their spatial locations
in the motor cortex. These data suggested that control of any finger
movement utilizes a distributed population of neurons. In this study
we applied the neuronal population vector analysis (Georgopoulos
et al., 1983) to these same data to determine (1) whether single
cells are tuned in an abstract, three-dimensional (3D) instructed
finger and wrist movement space with hand-like geometry and (2) whether
the neuronal population encodes specific finger movements. We found
that the activity of 132/176 (75%) motor cortical neurons related
to finger movements was indeed tuned in this space. Moreover, the
population vector computed in this space predicted well the instructed
finger movement. Thus, although single neurons may be related to
several disparate finger movements, and neurons related to different
finger movements are intermingled throughout the hand area of the
motor cortex, the neuronal population activity does specify particular
finger movements.
@article{Georgopoulos:1999,
abstract = {Previous work (Schieber and Hibbard, 1993) has shown that single motor
cortical neurons do not discharge specifically for a particular flexion-extension
finger movement but instead are active with movements of different
fingers. In addition, neuronal populations active with movements
of different fingers overlap extensively in their spatial locations
in the motor cortex. These data suggested that control of any finger
movement utilizes a distributed population of neurons. In this study
we applied the neuronal population vector analysis (Georgopoulos
et al., 1983) to these same data to determine (1) whether single
cells are tuned in an abstract, three-dimensional (3D) instructed
finger and wrist movement space with hand-like geometry and (2) whether
the neuronal population encodes specific finger movements. We found
that the activity of 132/176 (75%) motor cortical neurons related
to finger movements was indeed tuned in this space. Moreover, the
population vector computed in this space predicted well the instructed
finger movement. Thus, although single neurons may be related to
several disparate finger movements, and neurons related to different
finger movements are intermingled throughout the hand area of the
motor cortex, the neuronal population activity does specify particular
finger movements.},
added-at = {2009-06-26T15:25:19.000+0200},
author = {Georgopoulos, Apostolos P. and Pellizzer, Giuseppe and Poliakov, Andrew V. and Schieber, Marc H.},
biburl = {https://www.bibsonomy.org/bibtex/22ecb026eb5d27529c4f3b42427103afa/butz},
description = {diverse cognitive systems bib},
interhash = {89ece3151bc444b93be6988653453037},
intrahash = {2ecb026eb5d27529c4f3b42427103afa},
journal = {Journal of Computational Neuroscience},
keywords = {- finger movements population tuning vector},
owner = {butz},
pages = {279-288},
timestamp = {2009-06-26T15:25:30.000+0200},
title = {Neural Coding of Finger and Wrist Movements},
volume = 6,
year = 1999
}