Determining changes in NIR absorption using a layered model of the
human head
(2001)Abstract
A theoretical approach is presented to determine absorption changes
in different compartments of a layered structure from distributions
of times of flight of photons. In addition resulting changes in spatial
profiles of time-integrated intensity and mean time of flight are
calculated. The capability of a single-distance, time-domain method
to determine absorption changes with depth resolution is tested on
a layered phantom. We apply this method to in vivo measurements
on the human head (motor stimulation, Valsalva manoeuvre) and introduce
a small-sized time-domain experimental set-up suitable for bedside
monitoring.