Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.
Description
Cancer stem cells: small subpopulation or evolving fraction? - Integrative Biology (RSC Publishing)
%0 Journal Article
%1 enderling2015cancer
%A Enderling, Heiko
%D 2015
%I The Royal Society of Chemistry
%J Integr. Biol.
%K cancer phd stemcell
%P -
%R 10.1039/C4IB00191E
%T Cancer stem cells: small subpopulation or evolving fraction?
%U http://dx.doi.org/10.1039/C4IB00191E
%X Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.
@article{enderling2015cancer,
abstract = {Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate{,} propagate{,} and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel{,} integrated interdisciplinary studies is offered.},
added-at = {2014-11-18T14:27:28.000+0100},
author = {Enderling, Heiko},
biburl = {https://www.bibsonomy.org/bibtex/23d2830fed2ebca01678a56a4d2e8bbd1/bkoch},
description = {Cancer stem cells: small subpopulation or evolving fraction? - Integrative Biology (RSC Publishing)},
doi = {10.1039/C4IB00191E},
interhash = {c0a58fe666aac1187dfe34942d517f43},
intrahash = {3d2830fed2ebca01678a56a4d2e8bbd1},
journal = {Integr. Biol.},
keywords = {cancer phd stemcell},
pages = {-},
publisher = {The Royal Society of Chemistry},
timestamp = {2014-11-18T14:27:28.000+0100},
title = {Cancer stem cells: small subpopulation or evolving fraction?},
url = {http://dx.doi.org/10.1039/C4IB00191E},
year = 2015
}