Hyperphosphorylated tau protein which can be isolated on the basis of insolubility in 1% sarkosyl (A68-tau fraction) is thought to represent a precursor pool for PHF assembly, associated histologically with neuritic pathology, which feeds into a more resistant tangle-associated PHF pool via cross-linking and proteolysis. We examined these predictions at the earliest detectable stages of neurofibrillary pathology. We report that there is no evidence that neuritic pathology represents an early pathologic stage, no evidence of an association between neuritic pathology and phosphorylated tau, no evidence of selective accumulation of phosphorylated tau at early stages of pathology, and no evidence for a precursor/product relationship between phosphorylated tau and PHFs during progression of pathology. We conclude that altered phosphorylation is a secondary process affecting 5% of PHFs and does not explain PHF assembly in Alzheimer's disease.
%0 Journal Article
%1 lai1995examinationdisease.
%A Lai, RY
%A Gertz, HN
%A Wischik, DJ
%A Xuereb, JH
%A Mukaetova-Ladinska, EB
%A Harrington, CR
%A Edwards, PC
%A Mena, R
%A Paykel, ES
%A Brayne, C
%C Cambridge Brain Bank Laboratory, Department of Psychiatry, MRC Centre, United Kingdom.
%D 1995
%J Neurobiol Aging
%K imported
%N 3
%P 433--445
%T Examination of phosphorylated tau protein as a PHF-precursor at early stage Alzheimer's disease.
%U http://www.ncbi.nlm.nih.gov/pubmed/7566351
%V 16
%X Hyperphosphorylated tau protein which can be isolated on the basis of insolubility in 1% sarkosyl (A68-tau fraction) is thought to represent a precursor pool for PHF assembly, associated histologically with neuritic pathology, which feeds into a more resistant tangle-associated PHF pool via cross-linking and proteolysis. We examined these predictions at the earliest detectable stages of neurofibrillary pathology. We report that there is no evidence that neuritic pathology represents an early pathologic stage, no evidence of an association between neuritic pathology and phosphorylated tau, no evidence of selective accumulation of phosphorylated tau at early stages of pathology, and no evidence for a precursor/product relationship between phosphorylated tau and PHFs during progression of pathology. We conclude that altered phosphorylation is a secondary process affecting 5% of PHFs and does not explain PHF assembly in Alzheimer's disease.
@article{lai1995examinationdisease.,
abstract = {Hyperphosphorylated tau protein which can be isolated on the basis of insolubility in 1% sarkosyl (A68-tau fraction) is thought to represent a precursor pool for PHF assembly, associated histologically with neuritic pathology, which feeds into a more resistant tangle-associated PHF pool via cross-linking and proteolysis. We examined these predictions at the earliest detectable stages of neurofibrillary pathology. We report that there is no evidence that neuritic pathology represents an early pathologic stage, no evidence of an association between neuritic pathology and phosphorylated tau, no evidence of selective accumulation of phosphorylated tau at early stages of pathology, and no evidence for a precursor/product relationship between phosphorylated tau and PHFs during progression of pathology. We conclude that altered phosphorylation is a secondary process affecting 5% of PHFs and does not explain PHF assembly in Alzheimer's disease.},
added-at = {2013-08-12T12:53:15.000+0200},
address = {Cambridge Brain Bank Laboratory, Department of Psychiatry, MRC Centre, United Kingdom.},
author = {Lai, RY and Gertz, HN and Wischik, DJ and Xuereb, JH and Mukaetova-Ladinska, EB and Harrington, CR and Edwards, PC and Mena, R and Paykel, ES and Brayne, C},
biburl = {https://www.bibsonomy.org/bibtex/242fdec565d283a47fe4eab3cb572b4bf/sokratesagogo},
interhash = {f50c8c134fdfaa3b01a75d7fe44d77d9},
intrahash = {42fdec565d283a47fe4eab3cb572b4bf},
issn = {0197-4580},
journal = {Neurobiol Aging},
keyword = {Aged},
keywords = {imported},
language = {eng},
month = May,
number = 3,
organization = {UNITED STATES},
pages = {433--445},
pii = {019745809500041C},
timestamp = {2013-08-12T12:53:34.000+0200},
title = {Examination of phosphorylated tau protein as a PHF-precursor at early stage Alzheimer's disease.},
url = {http://www.ncbi.nlm.nih.gov/pubmed/7566351},
volume = 16,
year = 1995
}