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Comparing DNA Sequence Collections by Direct Comparison of Compressed Text Indexes

, , , and . Algorithms in Bioinformatics, volume 7534 of Lecture Notes in Computer Science, Springer Berlin Heidelberg, (2012)
DOI: 10.1007/978-3-642-33122-0_17

Abstract

Popular sequence alignment tools such as BWA convert a reference genome to an indexing data structure based on the Burrows-Wheeler Transform (BWT), from which matches to individual query sequences can be rapidly determined. However the utility of also indexing the query sequences themselves remains relatively unexplored.

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