%0 Journal Article %1 Grass.2011 %A Grass, Sandra %A Iida, Shinsuke %A Wikowicz, Aleksandra %A Preuss, Klaus-Dieter %A Inagaki, Atsushi %A Shimizu, Kazuyuki %A Ziepert, Marita %A Ueda, Ryuzo %A Pfreundschuh, Michael %D 2011 %J Cancer science %K Asian_Continental_Ancestry_Group Blood_Proteins/analysis/physiology Enzyme-Linked_Immunosorbent_Assay Genes,_Dominant Germany Humans Membrane_Proteins/analysis/physiology Monoclonal_Gammopathy_of_Undetermined_Significance/etiology/genetics Multiple_Myeloma/etiology/genetics Paraproteins/physiology Phosphorylation Risk_Factors %N 3 %P 565–568 %T Risk of Japanese carriers of hyperphosphorylated paratarg-7, the first autosomal-dominantly inherited risk factor for hematological neoplasms, to develop monoclonal gammopathy of undetermined significance and multiple myeloma %V 102 %X Hyperphosphorylated paratarg-7 (pP-7) is a frequent target of paraproteins in German patients with monoclonal gammopathy of undetermined significance (MGUS)/multiple myeloma (MM). The frequency of MGUS/MM is lower in Japan than in Europe. As pP-7, the first molecularly defined autosomal-dominant risk factor for any hematological neoplasm, is inherited in a dominant fashion, we determined the incidence of the pP-7 carrier state in a Japanese population, and compared the frequency of pP-7-specific paraproteins and the pP-7 carrier state in Japanese and German patients with MGUS/MM. Peripheral blood from 111 Japanese patients with MGUS/MM and 278 healthy blood donors was analyzed for the pP-7 carrier state by isoelectric focusing and for pP-7-specific antibodies by ELISA. The Japanese group was compared with 252 German MGUS/MM patients and 200 healthy controls. Five of 111 (4.5\%) Japanese and 35/252 (13.9\%) German IgA/IgG MGUS/MM patients had a pP-7-specific paraprotein (P=0.009). The prevalence of healthy pP-7 carriers in the Japanese study group was 1/278 (0.36\%), whereas it was 4/200 in the German group (P=0.166). The relative risk for pP-7 carriers developing MGUS/MM had an odds ratio of 13.1 in the Japanese and 7.9 in the German group. In conclusion, the fraction of pP-7 carriers with a pP-7-specific paraprotein is lower among Japanese than in German patients with MGUS/MM, but pP-7 carriers in both ethnic groups have a high risk of developing MGUS/MM.

@article{Grass.2011, abstract = {Hyperphosphorylated paratarg-7 (pP-7) is a frequent target of paraproteins in German patients with monoclonal gammopathy of undetermined significance (MGUS)/multiple myeloma (MM). The frequency of MGUS/MM is lower in Japan than in Europe. As pP-7, the first molecularly defined autosomal-dominant risk factor for any hematological neoplasm, is inherited in a dominant fashion, we determined the incidence of the pP-7 carrier state in a Japanese population, and compared the frequency of pP-7-specific paraproteins and the pP-7 carrier state in Japanese and German patients with MGUS/MM. Peripheral blood from 111 Japanese patients with MGUS/MM and 278 healthy blood donors was analyzed for the pP-7 carrier state by isoelectric focusing and for pP-7-specific antibodies by ELISA. The Japanese group was compared with 252 German MGUS/MM patients and 200 healthy controls. Five of 111 (4.5\%) Japanese and 35/252 (13.9\%) German IgA/IgG MGUS/MM patients had a pP-7-specific paraprotein (P=0.009). The prevalence of healthy pP-7 carriers in the Japanese study group was 1/278 (0.36\%), whereas it was 4/200 in the German group (P=0.166). The relative risk for pP-7 carriers developing MGUS/MM had an odds ratio of 13.1 in the Japanese and 7.9 in the German group. In conclusion, the fraction of pP-7 carriers with a pP-7-specific paraprotein is lower among Japanese than in German patients with MGUS/MM, but pP-7 carriers in both ethnic groups have a high risk of developing MGUS/MM.}, added-at = {2014-10-14T15:27:58.000+0200}, author = {Grass, Sandra and Iida, Shinsuke and Wikowicz, Aleksandra and Preuss, Klaus-Dieter and Inagaki, Atsushi and Shimizu, Kazuyuki and Ziepert, Marita and Ueda, Ryuzo and Pfreundschuh, Michael}, biburl = {https://www.bibsonomy.org/bibtex/248e53eaf4a179eb4d85f43ec151046d4/drtester}, interhash = {b9375c77a262c3f5f0eaabeb68427af4}, intrahash = {48e53eaf4a179eb4d85f43ec151046d4}, journal = {Cancer science}, keywords = {Asian_Continental_Ancestry_Group Blood_Proteins/analysis/physiology Enzyme-Linked_Immunosorbent_Assay Genes,_Dominant Germany Humans Membrane_Proteins/analysis/physiology Monoclonal_Gammopathy_of_Undetermined_Significance/etiology/genetics Multiple_Myeloma/etiology/genetics Paraproteins/physiology Phosphorylation Risk_Factors}, number = 3, pages = {565–568}, timestamp = {2014-10-14T15:27:58.000+0200}, title = {Risk of Japanese carriers of hyperphosphorylated paratarg-7, the first autosomal-dominantly inherited risk factor for hematological neoplasms, to develop monoclonal gammopathy of undetermined significance and multiple myeloma}, volume = 102, year = 2011 }