Ten exclusively gastrostomy-fed, neurologically impaired children (4.5-14.5 years old) with gastroesophageal reflux were randomly assigned to receive feedings with either a casein- or a whey-based formula for 48 h each and then crossed over to the other formula. One 24-h pH probe study each was performed while being fed casein- and whey-based formula, respectively. There was a significant reduction in episodes and duration of gastroesophageal reflux while consuming the whey-based formula (p < 0.05). Whey-based feedings should be considered an additional tool in conjunction with other antireflux measures to treat gastroesophageal reflux more effectively in children with severe neurological impairment. A similar study was also conducted involving 14 infants (3-12 months old) with documented gastroesophageal reflux using 24-h pH probe monitoring while consuming a casein-based formula. The formula was changed to a whey-based formula and the pH probe study repeated within 3-5 days. Four infants showed improvement and the rest showed either deterioration (1/14) or comparable results (9/14). The reduction in the mean number of episodes or duration of gastroesophageal reflux with the whey-formula was not significantly different from that with the casein-based formula (p > 0.05). Based on these findings, generalized recommendations for the use of whey-based formula in infants with gastroesophageal reflux cannot be made.
%0 Journal Article
%1 Khoshoo1996
%A Khoshoo, V.
%A Zembo, M.
%A King, A.
%A Dhar, M.
%A Reifen, R.
%A Pencharz, P.
%D 1996
%J J Pediatr Gastroenterol Nutr
%K Adolescent; Caseins; Cerebral Palsy; Child; Child, Preschool; Cross-Over Studies; Female; Food, Formulated; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Milk Proteins
%N 1
%P 48--55
%T Incidence of gastroesophageal reflux with whey- and casein-based formulas in infants and in children with severe neurological impairment.
%V 22
%X Ten exclusively gastrostomy-fed, neurologically impaired children (4.5-14.5 years old) with gastroesophageal reflux were randomly assigned to receive feedings with either a casein- or a whey-based formula for 48 h each and then crossed over to the other formula. One 24-h pH probe study each was performed while being fed casein- and whey-based formula, respectively. There was a significant reduction in episodes and duration of gastroesophageal reflux while consuming the whey-based formula (p < 0.05). Whey-based feedings should be considered an additional tool in conjunction with other antireflux measures to treat gastroesophageal reflux more effectively in children with severe neurological impairment. A similar study was also conducted involving 14 infants (3-12 months old) with documented gastroesophageal reflux using 24-h pH probe monitoring while consuming a casein-based formula. The formula was changed to a whey-based formula and the pH probe study repeated within 3-5 days. Four infants showed improvement and the rest showed either deterioration (1/14) or comparable results (9/14). The reduction in the mean number of episodes or duration of gastroesophageal reflux with the whey-formula was not significantly different from that with the casein-based formula (p > 0.05). Based on these findings, generalized recommendations for the use of whey-based formula in infants with gastroesophageal reflux cannot be made.
@article{Khoshoo1996,
abstract = {Ten exclusively gastrostomy-fed, neurologically impaired children (4.5-14.5 years old) with gastroesophageal reflux were randomly assigned to receive feedings with either a casein- or a whey-based formula for 48 h each and then crossed over to the other formula. One 24-h pH probe study each was performed while being fed casein- and whey-based formula, respectively. There was a significant reduction in episodes and duration of gastroesophageal reflux while consuming the whey-based formula (p < 0.05). Whey-based feedings should be considered an additional tool in conjunction with other antireflux measures to treat gastroesophageal reflux more effectively in children with severe neurological impairment. A similar study was also conducted involving 14 infants (3-12 months old) with documented gastroesophageal reflux using 24-h pH probe monitoring while consuming a casein-based formula. The formula was changed to a whey-based formula and the pH probe study repeated within 3-5 days. Four infants showed improvement and the rest showed either deterioration (1/14) or comparable results (9/14). The reduction in the mean number of episodes or duration of gastroesophageal reflux with the whey-formula was not significantly different from that with the casein-based formula (p > 0.05). Based on these findings, generalized recommendations for the use of whey-based formula in infants with gastroesophageal reflux cannot be made.},
added-at = {2014-07-19T20:36:49.000+0200},
author = {Khoshoo, V. and Zembo, M. and King, A. and Dhar, M. and Reifen, R. and Pencharz, P.},
biburl = {https://www.bibsonomy.org/bibtex/24e04641b98886b85b62f11b5616eba16/ar0berts},
groups = {public},
interhash = {42588355c059c72c43eaceb394b834b8},
intrahash = {4e04641b98886b85b62f11b5616eba16},
journal = {J Pediatr Gastroenterol Nutr},
keywords = {Adolescent; Caseins; Cerebral Palsy; Child; Child, Preschool; Cross-Over Studies; Female; Food, Formulated; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Milk Proteins},
month = Jan,
number = 1,
pages = {48--55},
pmid = {8788287},
timestamp = {2014-07-19T20:36:49.000+0200},
title = {Incidence of gastroesophageal reflux with whey- and casein-based formulas in infants and in children with severe neurological impairment.},
username = {ar0berts},
volume = 22,
year = 1996
}