Xenopus Cadherin-11 (Xcad-11) is expressed when cranial neural crest cells (CNC) acquire motility. However, its function in stimulating cell migration is poorly understood. Here, we demonstrate that Xcad-11 initiates filopodia and lamellipodia formation, which is essential for CNC to populate pharyngeal pouches. We identified the cytoplasmic tail of Xcad-11 as both necessary and sufficient for proper CNC migration as long as it was linked to the plasma membrane. Our results showing that guanine nucleotide exchange factor (GEF)-Trio binds to Xcad-11 and can functionally substitute for it like constitutively active forms of RhoA, Rac, and cdc42 unravel a novel cadherin function.
%0 Journal Article
%1 Kashef:2009:Genes-Dev:19528317
%A Kashef, J
%A Köhler, A
%A Kuriyama, S
%A Alfandari, D
%A Mayor, R
%A Wedlich, D
%D 2009
%J Genes Dev
%K biology development xenopus
%N 12
%P 1393-1398
%R 10.1101/gad.519409
%T Cadherin-11 regulates protrusive activity in Xenopus cranial neural crest cells upstream of Trio and the small GTPases
%U http://www.ncbi.nlm.nih.gov/pubmed/19528317
%V 23
%X Xenopus Cadherin-11 (Xcad-11) is expressed when cranial neural crest cells (CNC) acquire motility. However, its function in stimulating cell migration is poorly understood. Here, we demonstrate that Xcad-11 initiates filopodia and lamellipodia formation, which is essential for CNC to populate pharyngeal pouches. We identified the cytoplasmic tail of Xcad-11 as both necessary and sufficient for proper CNC migration as long as it was linked to the plasma membrane. Our results showing that guanine nucleotide exchange factor (GEF)-Trio binds to Xcad-11 and can functionally substitute for it like constitutively active forms of RhoA, Rac, and cdc42 unravel a novel cadherin function.
@article{Kashef:2009:Genes-Dev:19528317,
abstract = {Xenopus Cadherin-11 (Xcad-11) is expressed when cranial neural crest cells (CNC) acquire motility. However, its function in stimulating cell migration is poorly understood. Here, we demonstrate that Xcad-11 initiates filopodia and lamellipodia formation, which is essential for CNC to populate pharyngeal pouches. We identified the cytoplasmic tail of Xcad-11 as both necessary and sufficient for proper CNC migration as long as it was linked to the plasma membrane. Our results showing that guanine nucleotide exchange factor (GEF)-Trio binds to Xcad-11 and can functionally substitute for it like constitutively active forms of RhoA, Rac, and cdc42 unravel a novel cadherin function.},
added-at = {2014-09-09T18:33:13.000+0200},
author = {Kashef, J and K{\"o}hler, A and Kuriyama, S and Alfandari, D and Mayor, R and Wedlich, D},
biburl = {https://www.bibsonomy.org/bibtex/250f79723e9d68d5359c94dbd331639e2/alex_ruff},
description = {Cadherin-11 regulates protrusive activity in Xenop... [Genes Dev. 2009] - PubMed - NCBI},
doi = {10.1101/gad.519409},
interhash = {6f79e86be7992a6fc86d6c032259d2c0},
intrahash = {50f79723e9d68d5359c94dbd331639e2},
journal = {Genes Dev},
keywords = {biology development xenopus},
month = jun,
number = 12,
pages = {1393-1398},
pmid = {19528317},
timestamp = {2014-09-09T18:33:13.000+0200},
title = {Cadherin-11 regulates protrusive activity in Xenopus cranial neural crest cells upstream of Trio and the small GTPases},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19528317},
volume = 23,
year = 2009
}