%0 Journal Article %1 Bret_2003_1182 %A Brette, Fabien %A Orchard, Clive %D 2003 %J Circ. Res. %K 12805236 ATPase, Animals, Calcium, Capacitance, Cardiac, Cardiomegaly, Cell Cells, Comparative Congestive, Cultured, Distribution, Electric Failure, Gov't, Guinea Heart Heart, Humans, Ion Mammals, Membrane Mice, Myocytes, Non-U.S. P.H.S., Pigs, Potentials, Proteins, Rabbits, Rats, Research Sarcolemma, Signal Size, Sodium, Study, Support, Swine, Tissue Transduction, Transport, U.S. Ventricles, {N}a$^{+}$-{K}$^{+}$-Exchanging %N 11 %P 1182--1192 %R 10.1161/01.RES.0000074908.17214.FD %T T-tubule function in mammalian cardiac myocytes. %U http://dx.doi.org/10.1161/01.RES.0000074908.17214.FD %V 92 %X The transverse tubules (t-tubules) of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent studies have suggested that the structure and function of the t-tubules are more complex than previously believed; in particular, many of the proteins involved in cellular Ca$^2+$ cycling appear to be concentrated at the t-tubule. Thus, the t-tubules are an important determinant of cardiac cell function, especially as the main site of excitation-contraction coupling, ensuring spatially and temporally synchronous Ca$^2+$ release throughout the cell. Changes in t-tubule structure and protein expression occur during development and in heart failure, so that changes in the t-tubules may contribute to the functional changes observed in these conditions. The purpose of this review is to provide an overview of recent studies of t-tubule structure and function in cardiac myocytes.

@article{Bret_2003_1182, abstract = {The transverse tubules (t-tubules) of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent studies have suggested that the structure and function of the t-tubules are more complex than previously believed; in particular, many of the proteins involved in cellular {C}a$^{2+}$ cycling appear to be concentrated at the t-tubule. Thus, the t-tubules are an important determinant of cardiac cell function, especially as the main site of excitation-contraction coupling, ensuring spatially and temporally synchronous {C}a$^{2+}$ release throughout the cell. Changes in t-tubule structure and protein expression occur during development and in heart failure, so that changes in the t-tubules may contribute to the functional changes observed in these conditions. The purpose of this review is to provide an overview of recent studies of t-tubule structure and function in cardiac myocytes.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Brette, Fabien and Orchard, Clive}, biburl = {https://www.bibsonomy.org/bibtex/252432b371bdefaa9e6a220b57e891cac/hake}, description = {The whole bibliography file I use.}, doi = {10.1161/01.RES.0000074908.17214.FD}, file = {Bret_2003_1182.pdf:Bret_2003_1182.pdf:PDF}, interhash = {48fbd64905e4c476789f846d06d78fe6}, intrahash = {52432b371bdefaa9e6a220b57e891cac}, journal = {Circ. Res.}, key = 53, keywords = {12805236 ATPase, Animals, Calcium, Capacitance, Cardiac, Cardiomegaly, Cell Cells, Comparative Congestive, Cultured, Distribution, Electric Failure, Gov't, Guinea Heart Heart, Humans, Ion Mammals, Membrane Mice, Myocytes, Non-U.S. P.H.S., Pigs, Potentials, Proteins, Rabbits, Rats, Research Sarcolemma, Signal Size, Sodium, Study, Support, Swine, Tissue Transduction, Transport, U.S. Ventricles, {N}a$^{+}$-{K}$^{+}$-Exchanging}, month = Jun, number = 11, pages = {1182--1192}, pii = {92/11/1182}, pmid = {12805236}, timestamp = {2009-06-03T11:21:06.000+0200}, title = {T-tubule function in mammalian cardiac myocytes.}, url = {http://dx.doi.org/10.1161/01.RES.0000074908.17214.FD}, volume = 92, year = 2003 }