%0 Journal Article %1 Macia2012Distributed %A Mac\'ıa, Javier %A Posas, Francesc %A Solé, Ricard V. %D 2012 %J Trends in Biotechnology %K biological-computation synthetic-biology %N 6 %P 342--349 %R 10.1016/j.tibtech.2012.03.006 %T Distributed computation: the new wave of synthetic biology devices %U http://dx.doi.org/10.1016/j.tibtech.2012.03.006 %V 30 %X Synthetic biology (SB) offers a unique opportunity for designing complex molecular circuits able to perform predefined functions. But the goal of achieving a flexible toolbox of reusable molecular components has been shown to be limited due to circuit unpredictability, incompatible parts or random fluctuations. Many of these problems arise from the challenges posed by engineering the molecular circuitry: multiple wires are usually difficult to implement reliably within one cell and the resulting systems cannot be reused in other modules. These problems are solved by means of a nonstandard approach to single cell devices, using cell consortia and allowing the output signal to be distributed among different cell types, which can be combined in multiple, reusable and scalable ways. Copyright \copyright 2012 Elsevier Ltd. All rights reserved.

@article{Macia2012Distributed, abstract = { Synthetic biology ({SB}) offers a unique opportunity for designing complex molecular circuits able to perform predefined functions. But the goal of achieving a flexible toolbox of reusable molecular components has been shown to be limited due to circuit unpredictability, incompatible parts or random fluctuations. Many of these problems arise from the challenges posed by engineering the molecular circuitry: multiple wires are usually difficult to implement reliably within one cell and the resulting systems cannot be reused in other modules. These problems are solved by means of a nonstandard approach to single cell devices, using cell consortia and allowing the output signal to be distributed among different cell types, which can be combined in multiple, reusable and scalable ways. Copyright {\copyright} 2012 Elsevier Ltd. All rights reserved. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Mac\'{\i}a, Javier and Posas, Francesc and Sol\'{e}, Ricard V.}, biburl = {https://www.bibsonomy.org/bibtex/25f0ed0fb82e3693663f8b81ccc9d441d/karthikraman}, citeulike-article-id = {10583069}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tibtech.2012.03.006}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/22516742}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=22516742}, doi = {10.1016/j.tibtech.2012.03.006}, interhash = {ea81b061bfb0abd4901714571de2e33c}, intrahash = {5f0ed0fb82e3693663f8b81ccc9d441d}, issn = {01677799}, journal = {Trends in Biotechnology}, keywords = {biological-computation synthetic-biology}, month = jun, number = 6, pages = {342--349}, pmid = {22516742}, posted-at = {2012-06-18 07:05:32}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Distributed computation: the new wave of synthetic biology devices}, url = {http://dx.doi.org/10.1016/j.tibtech.2012.03.006}, volume = 30, year = 2012 }